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Polymorphonuclear Neutrophils and Cancer. Intense and Sustained Neutrophilia as a Treatment Against Solid Tumors

Brú Espino, Antonio and Souto, Juan Carlos and Vila, Luis (2011) Polymorphonuclear Neutrophils and Cancer. Intense and Sustained Neutrophilia as a Treatment Against Solid Tumors. Medicinal Research Reviews, 31 (3). pp. 311-363. ISSN 0198-6325

Official URL: http://onlinelibrary.wiley.com/doi/10.1002/med.20185/pdf

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Abstract

Polymorphonuclear neutrophils (PMN) are the most abundant circulating immune cells and represent the first line of immune defense against infection. This review of the biomedical literature of the last 40 years shows that they also have a powerful antitumoral effect under certain circumstances. Typically, the microenvironment surrounding a solid tumor possesses many of the characteristics of chronic inflammation, a condition considered very favorable for tumor growth and spread. However, there are many circumstances that shift the chronic inflammatory state toward an acute inflammatory response around a tumor. This shift seems to convert PMN into very efficient anticancer effector cells. Clinical reports of unexpected antitumoral effects linked to the prolonged use of granulocyte colony-stimulating factor, which stimulates an intense and sustained neutrophilia, suggest that an easy way to fight solid tumors would be to encourage the development of intense peritumoral PMN infiltrates. Specifically designed clinical trials are urgently needed to evaluate the safety and efficacy of such drug-induced neutrophilia in patients with solid tumors. This antitumoral role of neutrophils may provide new avenues for the clinical treatment of cancer.


Item Type:Article
Uncontrolled Keywords:Colony-stimulating factor; mediated cyto-toxicity; dependent cellular cytotoxicity; fc-gamma-ri; bacillus-calmette-guerin; mammary adenocarcinoma cells; superficial bladder-cancer; host-parasite interactions; streptococcal preparation ok-432; chronic granulocytic leukemia; cancer; neutrophils; tumor growth; acute inflammation; innate immunity
Subjects:Sciences > Mathematics > Operations research
ID Code:14817
Deposited On:18 Apr 2012 10:25
Last Modified:18 Apr 2012 10:25

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