Complutense University Library

Mathematical Modeling of Tuberculosis Bacillary Counts and Cellular Populations in the Organs of Infected Mice

Brú Espino, Antonio and Cardona, Pere Joan (2010) Mathematical Modeling of Tuberculosis Bacillary Counts and Cellular Populations in the Organs of Infected Mice. Plos One, 5 (9). ISSN 1932-6203

[img] PDF
Restricted to Repository staff only until 31 December 2020.

13MB

Official URL: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0012985

View download statistics for this eprint

==>>> Export to other formats

Abstract

Background: Mycobacterium tuberculosis is a particularly aggressive microorganism and the host's defense is based on the induction of cellular immunity, in which the creation of a granulomatous structure has an important role. Methodology: We present here a new 2D cellular automata model based on the concept of a multifunctional process that includes key factors such as the chemokine attraction of the cells; the role of innate immunity triggered by natural killers; the presence of neutrophils; apoptosis and necrosis of infected macrophages; the removal of dead cells by macrophages, which induces the production of foamy macrophages (FMs); the life cycle of the bacilli as a determinant for the evolution of infected macrophages; and the immune response. Results: The results obtained after the inclusion of two degrees of tolerance to the inflammatory response triggered by the infection shows that the model can cover a wide spectrum, ranging from highly-tolerant (i.e. mice) to poorly-tolerant hosts (i.e. mini-pigs or humans). Conclusions: This model suggest that stopping bacillary growth at the onset of the infection might be difficult and the important role played by FMs in bacillary drainage in poorly-tolerant hosts together with apoptosis and innate lymphocytes. It also shows the poor ability of the cellular immunity to control the infection, provides a clear protective character to the granuloma, due its ability to attract a sufficient number of cells, and explains why an already infected host can be constantly reinfected.


Item Type:Article
Uncontrolled Keywords:Tumor-necrosis-factor; mycobacterium-tuberculosis; pulmonary tuberculosis; protective immunity; granuloma-formation; murine macrophages; tubercle-bacilli; serum therapy; bcg infection; in-vitro
Subjects:Sciences > Mathematics > Mathematical analysis
ID Code:14818
Deposited On:18 Apr 2012 10:23
Last Modified:06 Feb 2014 10:10

Repository Staff Only: item control page