Biblioteca de la Universidad Complutense de Madrid

Tumour Cell Lines HT-29 and FaDu Produce Proinflammatory Cytokines and Activate Neutrophils In Vitro: Possible Applications for Neutrophil-Based Antitumour Treatment

Impacto

Bru Espino, Antonio y Souto Andres, Joan Carles y Alcolea, Sonia y Anton, Rosa y Remacha, Angel y Camacho, Mercedes y Soler, Marta y Bru, Isabel y Porres, Amelia y Vila, Luis (2009) Tumour Cell Lines HT-29 and FaDu Produce Proinflammatory Cytokines and Activate Neutrophils In Vitro: Possible Applications for Neutrophil-Based Antitumour Treatment. Mediators of Inflammation . ISSN 0962-9351

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URL Oficial: http://www.hindawi.com/journals/mi/2009/817498/



Resumen

There is evidence that polymorphonuclear neutrophils (PMNs) can exert severe antineoplastic effects. Cross-talk between tumour cells and endothelial cells (ECs) is necessary for the accumulation of PMN around a tumour. This work reports the ability of two PMN-sensitive, human, permanent cell lines-colorectal adenocarcinoma (HT-29) and pharyngeal squamous-cell carcinoma (FaDu) cells-to act as inflammatory foci. PMNs were cytotoxic to both lines, the adhesion of the PMNs to the tumour cells being important in this effect. The tumour cells released appreciable amounts of IL-8 and GRO alpha, and induced the transmigration of PMN through human microvascular-EC monolayers. Conditioning media associated with both lines induced the adhesion of PMN and the surface expression of ICAM-1 in microvascular-EC. In addition, FaDu-conditioning-medium strongly induced the production of proinflammatory cytokines by microvascular-EC. These results support the idea that tumour cells might normally induce a potent acute inflammatory response, leading to their own destruction.


Tipo de documento:Artículo
Palabras clave:Acute inflammatory response; granulocyte-mediated cytotoxicity; colony-stimulating factor; human-melanoma cells; polymorphonuclear leukocytes; immune-response; nonoxidative mechanisms; endothelial-cells; cancer patients; gro-alpha; cell biology; Immunology
Materias:Ciencias > Matemáticas > Análisis matemático
Código ID:14832
Depositado:18 Abr 2012 10:19
Última Modificación:18 Nov 2016 11:52

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