Carpio Rodríguez, Ana María and Peral, I. (2011) Propagation Failure Along Myelinated Nerves. Journal of nonlinear science, 21 (4). pp. 499-520. ISSN 0938-8974
Restricted to Repository staff only until 2020.
Propagation of traveling pulses in the myelinated Hodgkin-Huxley model is studied. The nerve impulse is a traveling wave with two components. At the Ranvier nodes, it behaves as a discrete traveling pulse. Wave motion through the internodal regions is then driven by this traveling pulse. We give analytical characterizations of the parameter ranges for which nerve impulses fail to propagate by exploiting time scale separation and the active node approximation, which reduces the dynamics of infinite fibers to the evolution of a few nodes. Simple recipes to predict the speed of the impulses and the widths of their peaks are also given. Predictions are in good agreement with the information provided by numerical simulations.
|Uncontrolled Keywords:||Travelling waves · Propagation failure · Myelinated nerves · Reaction–diffusion systems|
|Subjects:||Medical sciences > Biology > Biomathematics|
Sciences > Mathematics > Differential equations
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|Deposited On:||19 Apr 2012 08:13|
|Last Modified:||06 Feb 2014 10:11|
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