Biblioteca de la Universidad Complutense de Madrid

Pinning of tumoral growth by enhancement of the immune response

Impacto

Bru Espino, Antonio y Albertos, Sonia y López García-Asenjo, J.A y Brú, Isabel (2004) Pinning of tumoral growth by enhancement of the immune response. Physical Review Letters, 92 (23). ISSN 0031-9007

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URL Oficial: http://prl.aps.org/pdf/PRL/v92/i23/e238101



Resumen

Tumor growth is a surface phenomenon of the molecular beam epitaxy universality class in which diffusion at the surface is the determining factor. This Letter reports experiments performed in mice showing that these dynamics can, however, be changed. By stimulating the immune response, we induced strong neutrophilia around the tumor. The neutrophils hindered cell surface diffusion so much that they induced new dynamics compatible with the slower quenched-disorder Edwards-Wilkinson universality class. Important clinical effects were also seen, including remarkably high tumor necrosis (around 80%-90% of the tumor), a general increase in survival time [the death ratio in the control group is 15.76 times higher than in the treated group (equivalent to a Cox's model hazard ratio of 0.85; 95% confidence interval 0.76-0.95, p=0.004)], and even the total elimination of some tumors.


Tipo de documento:Artículo
Palabras clave:interface; dynamics; models; continuum
Materias:Ciencias > Matemáticas > Análisis matemático
Código ID:14890
Depositado:19 Abr 2012 09:02
Última Modificación:18 Nov 2016 11:41

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