Universidad Complutense de Madrid
E-Prints Complutense

Mathematical modeling for protein folding devices. Applications to high pressure processing and microfluidic mixers.

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Bello Rivas, Juan y Infante del Río, Juan Antonio y Ivorra, Benjamin y López Redondo, Juana y Martínez Ortigosa, Pilar y Ramos del Olmo, Ángel Manuel y Rey Cabezas, Jose María y Smith, Nadia A. S (2010) Mathematical modeling for protein folding devices. Applications to high pressure processing and microfluidic mixers. In Proceedings of the 2nd International Conference on Engineering Optimization: Book of Abstracts and CD-ROM Proceedings. Associação Portuguesa de Mecânica Teórica, Aplicada e Computacional, Lisboa. ISBN 978-989-9626430

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URL Oficial: http://www.dem.ist.utl.pt/engopt2010/Book_and_CD/Papers_CD_Final_Version/html/authors/i/Ivorra_Benjamin.html




Resumen

In this paper, we consider two particular devices used for protein folding. The first one is a microfluidic mixer that perform a folding process by mixing a protein solution with a solvent. We are interested in minimizing its mixing time by choosing suitable shape and flow conditions. The second one is related to food processing and we focus on the modeling and simulation of the temperature evolution inside a high pressure food treatment device. Some of the effects of such treatments is to unfold, and thus inactivate, certain enzymes inside the food sample. The behavior and stability of the proposed model is checked by numerical examples. Furthermore, a simplified version of this model is presented and compared in terms of accuracy and computational time.


Tipo de documento:Sección de libro
Información Adicional:

EngOpt 2010 (2nd International Conference On Engineering Optimization. Lisbon, 6-9 September 2010)

Palabras clave:High-Pressure; Protein folding; Mathematical modeling; Global Optimization.
Materias:Ciencias > Física > Física matemática
Código ID:23358
Depositado:25 Oct 2013 10:44
Última Modificación:15 Jun 2015 12:10

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