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Solving gap metabolites and blocked reactions in genome-scale models: application to the metabolic network of Blattabacterium cuenoti

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Ponce-de-Leon, Miguel y Montero, Francisco J y Peretó, Juli (2013) Solving gap metabolites and blocked reactions in genome-scale models: application to the metabolic network of Blattabacterium cuenoti. BMC Systems Biology, 7 (114). ISSN 1752-0509

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URL Oficial: http://www.biomedcentral.com/1752-0509/7/114



Resumen

Background:Metabolic reconstruction is the computational-based process that aims to elucidate the network of metabolites interconnected through reactions catalyzed by activities assigned to one or more genes. Reconstructed models may contain inconsistencies that appear as gap metabolites and blocked reactions. Although automatic methods for solving this problem have been previously developed, there are many situations where manual
curation is still needed.
Results:We introduce a general definition of gap metabolite that allows its detection in a straightforward manner.
Moreover, a method for the detection of Unconnected Modules, defined as isolated sets of blocked reactions
connected through gap metabolites, is proposed. The method has been successfully applied to the curation of
iCG238,the genome-scale metabolic model for the bacterium
Blattabacterium cuenoti, obligate endosymbiont of cockroaches.
Conclusion:We found the proposed approach to be a valuable tool for the curation of genome-scale metabolic
models. The outcome of its application to the genome-scale model B. cuenoti iCG238is a more accurate model ver-
sion named as B. cuenoti iMP240


Tipo de documento:Artículo
Palabras clave:Bacteria; genetics; metabolisms; symbiosis; biological model
Materias:Ciencias Biomédicas > Biología > Biomatemáticas
Ciencias Biomédicas > Biología > Insectos
Ciencias Biomédicas > Biología > Microbiología
Código ID:29337
Depositado:25 Mar 2015 11:59
Última Modificación:26 Mar 2015 09:29

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