Universidad Complutense de Madrid
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Magnesium substitution in brushite cements for enhanced bone tissue regeneration



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Cabrejos-Azama, Jatsué y Hamdan Alkhraisat, Mohammad y Rueda, Carmen y Torres García-Denche, Jesús y Blanco, Luis y López-Cabarcos, Enrique (2014) Magnesium substitution in brushite cements for enhanced bone tissue regeneration. Materials Science and Engineering C, 43 . pp. 403-410. ISSN 0928-4931

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URL Oficial: http://www.elsevier.com/locate/msec


We have synthesized calcium phosphate cements doped with different amounts of magnesium (Mg-CPC)with a twofold purpose: i)to evaluate in vitro the osteoblast cell response to this material and ii) to compare the bone regeneration capacity of the doped material with a calcium cement prepared without magnesium (CPC). Cell proliferation and in vivo response increased in the Mg-CPC's in comparison with CPC. The Mg-CPC's have promoted higher new bone formation than the CPC (p<0.05). The cytocompatibility and histomorfometric analysis performed in the rabbit calvaria showed that the incorporation of magnesium ions in CPC improves osteoblasts proliferation and provides higher new bone formation. The development of a bone substitute with controllable biodegradable properties and improved bone regeneration can be considered a step toward personalized therapy that can adapt to patient needs and clinical situations.

Tipo de documento:Artículo
Palabras clave:Calcium phosphate cement ; Brushite ; Magnesium ; Osteoblast ; Bone regeneration
Materias:Ciencias Biomédicas > Odontología > Materiales dentales
Código ID:29951
Depositado:06 May 2015 11:52
Última Modificación:08 May 2015 11:48

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