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Salmonella Typhimurium exploits inflammation to its own advantage in piglets

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Chirullo, Barbara y Pesciaroli, Michele y Drumo, Rosanna y Ruggeri, Jessica y Razzuoli, Elisabetta y Pistoia, Claudia y Petrucci, Paola y Martinelli, Nicola y Cucco, Lucilla y Moscati, Livia y Amadori, Massimo y Magistrali, Chiara F y Alborali, Giovanni L y Pasquali, Paolo (2015) Salmonella Typhimurium exploits inflammation to its own advantage in piglets. Frontiers in microbiology, 6 . p. 985. ISSN 1664-302X

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URL Oficial: https://doi.org/10.3389/fmicb.2015.00985



Resumen

Salmonella Typhimurium (S. Typhimurium) is responsible for foodborne zoonotic infections that, in humans, induce self-limiting gastroenteritis. The aim of this study was to evaluate whether the wild-type strain S. Typhimurium (STM14028) is able to exploit inflammation fostering an active infection. Due to the similarity between human and porcine diseases induced by S. Typhimurium, we used piglets as a model for salmonellosis and gastrointestinal research. This study showed that STM14028 is able to efficiently colonize in vitro porcine mono-macrophages and intestinal columnar epithelial (IPEC-J2) cells, and that the colonization significantly increases with LPS pre-treatment. This increase was then reversed by inhibiting the LPS stimulation through LPS antagonist, confirming an active role of LPS stimulation in STM14028-intracellular colonization. Moreover, LPS in vivo treatment increased cytokines blood level and body temperature at 4 h post infection, which is consistent with an acute inflammatory stimulus, capable to influence the colonization of STM14028 in different organs and tissues. The present study proves for the first time that in acute enteric salmonellosis, S. Typhimurium exploits inflammation for its benefit in piglets.


Tipo de documento:Artículo
Palabras clave:Salmonella typhimurium, inflammation, immune response, pig, salmonellosis
Materias:Ciencias Biomédicas > Veterinaria
Código ID:39616
Depositado:19 Dic 2016 16:50
Última Modificación:19 Dic 2016 16:50

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