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Spatial dynamics of bovine tuberculosis in the Autonomous Community of Madrid, Spain (2010-2012)

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Cruz Conty, Maria Luisa de la y Perez, Andres y Bezos Garrido, Javier y Pages, Enrique y Casal, Carmen y Carpintero, Jesus y Romero Martínez, Beatriz y Domínguez Rodríguez, Lucas y Barker, Christopher M y Diaz, Rosa y Álvarez Sánchez, Julio (2014) Spatial dynamics of bovine tuberculosis in the Autonomous Community of Madrid, Spain (2010-2012). PLoS ONE, 9 (12). e115632. ISSN 1932-6203

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URL Oficial: http://dx.doi.org/10.1371/journal.pone.0115632



Resumen

Progress in control of bovine tuberculosis (bTB) is often not uniform, usually due to the effect of one or more sometimes unknown epidemiological factors impairing the success of eradication programs. Use of spatial analysis can help to identify clusters of persistence of disease, leading to the identification of these factors thus allowing the implementation of targeted control measures, and may provide some insights of disease transmission, particularly when combined with molecular typing techniques. Here, the spatial dynamics of bTB in a high prevalence region of Spain were assessed during a three year period (2010-2012) using data from the eradication campaigns to detect clusters of positive bTB herds and of those infected with certain Mycobacterium bovis strains (characterized using spoligotyping and VNTR typing). In addition, the within-herd transmission coefficient (β) was estimated in infected herds and its spatial distribution and association with other potential outbreak and herd variables was evaluated. Significant clustering of positive herds was identified in the three years of the study in the same location ("high risk area"). Three spoligotypes (SB0339, SB0121 and SB1142) accounted for >70% of the outbreaks detected in the three years. VNTR subtyping revealed the presence of few but highly prevalent strains within the high risk area, suggesting maintained transmission in the area. The spatial autocorrelation found in the distribution of the estimated within-herd transmission coefficients in herds located within distances <14 km and the results of the spatial regression analysis, support the hypothesis of shared local factors affecting disease transmission in farms located at a close proximity.


Tipo de documento:Artículo
Materias:Ciencias Biomédicas > Veterinaria
Código ID:39630
Depositado:21 Dic 2016 08:58
Última Modificación:10 Ene 2017 11:39

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