Universidad Complutense de Madrid
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Polymyxin resistance caused by mgrB inactivation is not associated with significant biological cost in Klebsiella pneumoniae

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Cannatelli, Antonio y Santos López, Alfonso y Giani, Tommaso y González Zorn, Bruno y Rossolini, Gian Maria (2015) Polymyxin resistance caused by mgrB inactivation is not associated with significant biological cost in Klebsiella pneumoniae. Antimicrobial agents and chemotherapy, 59 (5). pp. 2898-900. ISSN 1098-6596

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URL Oficial: http://aac.asm.org/content/59/5/2898.full



Resumen

The inactivation of the mgrB gene, which encodes a negative-feedback regulator of the PhoPQ signaling system, was recently shown to be a common mutational mechanism responsible for acquired polymyxin resistance among carbapenemase-producing Klebsiella pneumoniae strains from clinical sources. In this work, we show that mgrB mutants can easily be selected in vitro from different K. pneumoniae lineages, and mgrB inactivation is not associated with a significant biological cost.


Tipo de documento:Artículo
Materias:Ciencias Biomédicas > Veterinaria
Código ID:39730
Depositado:09 Ene 2017 16:25
Última Modificación:09 Ene 2017 16:25

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