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Morphometric and neurochemical alterations found in l-BMAA treated rats

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Munck García, Estefanía de y Muñoz Sáez, Emma y Gómez Miguel, Begoña y Solas Alados, Mª Teresa y Martínez, Ana y Arahuetes, Rosa María (2015) Morphometric and neurochemical alterations found in l-BMAA treated rats. Environmental Toxicology and Pharmacology, 39 (3). pp. 1232-1245. ISSN 1382-6689

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URL Oficial: http://dx.doi.org/10.1016/j.etap.2015.04.022



Resumen

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive muscle paralysis that reflects the motoneurons’ degeneration. Several studies support the relationship between β-N-methylamino-L-alanine (L-BMAA), a neurotoxic amino acid produced by cyanobacteria and diatoms, and the sporadic occurrence of ALS and other neurodegenerative diseases. Therefore, the study of its neurotoxicity mechanisms has assumed great relevance in recent years.
Recently, our research team has proposed a sporadic ALS animal model by L-BMAA administration in rats, which displays many pathophysiological features of human ALS. In this paper, we deepen the characterization of this model corroborating the occurrence of alterations present in ALS patients such as decreased muscle volume, thinning of the motor cortex, enlarged brain's lateral ventricles, and alteration of both bulbar nuclei and neurotransmitters’ levels. Therefore, we conclude that L-BMAA treated rats could be a good model which mimics degenerative features that ALS causes in humans.


Tipo de documento:Artículo
Palabras clave:ALS; l-BMAA; Rat; Neurotransmitters; Motor cortex; NMR; Neurochemistry
Materias:Ciencias Biomédicas > Biología > Biología celular
Ciencias Biomédicas > Biología > Neurociencias
Código ID:41921
Depositado:27 Mar 2017 14:54
Última Modificación:08 Jun 2017 16:57

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