Universidad Complutense de Madrid
E-Prints Complutense

Eph/ephrins-mediated thymocyte–thymic epithelial cell interactions control numerous processes of thymus biology

Impacto

Downloads

Downloads per month over past year

García Ceca Hernández, Javier and Alfaro Sánchez, David and Montero Herradón, Sara and Tobajas, Esther and Muñoz, Juan José and Zapata González, Agustín (2015) Eph/ephrins-mediated thymocyte–thymic epithelial cell interactions control numerous processes of thymus biology. Frontiers in Immunology, 6 (333). ISSN 1664-3224

[img]
Preview
PDF
Creative Commons Attribution.

114kB

Official URL: http://dx.doi.org/10.3389/fimmu.2015.00333



Abstract

Numerous studies emphasize the relevance of thymocyte–thymic epithelial cell (TECs) interactions for the functional maturation of intrathymic T lymphocytes. The tyrosine kinase receptors, Ephs (erythropoietin-producing hepatocyte kinases) and their ligands, ephrins (Eph receptor interaction proteins), are molecules known to be involved in the regulation of numerous biological systems in which cell-to-cell interactions are particularly relevant. In the last years, we and other authors have demonstrated the importance of these molecules in the thymic functions and the T-cell development. In the present report, we review data on the effects of Ephs and ephrins in the functional maturation of both thymic epithelial microenvironment and thymocyte maturation as well as on their role in the lymphoid progenitor recruitment into the thymus.


Item Type:Article
Uncontrolled Keywords:thymocytes, thymic epithelium, Eph, ephrin, thymic cell seeding
Subjects:Medical sciences > Biology
Medical sciences > Biology > Cytology
ID Code:41965
Deposited On:28 Mar 2017 14:27
Last Modified:04 Apr 2017 09:48

Origin of downloads

Repository Staff Only: item control page