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Eph/ephrins-mediated thymocyte–thymic epithelial cell interactions control numerous processes of thymus biology

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García Ceca Hernández, Javier y Alfaro Sánchez, David y Montero Herradón, Sara y Tobajas, Esther y Muñoz, Juan José y Zapata González, Agustín (2015) Eph/ephrins-mediated thymocyte–thymic epithelial cell interactions control numerous processes of thymus biology. Frontiers in Immunology, 6 (333). ISSN 1664-3224

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URL Oficial: http://dx.doi.org/10.3389/fimmu.2015.00333



Resumen

Numerous studies emphasize the relevance of thymocyte–thymic epithelial cell (TECs) interactions for the functional maturation of intrathymic T lymphocytes. The tyrosine kinase receptors, Ephs (erythropoietin-producing hepatocyte kinases) and their ligands, ephrins (Eph receptor interaction proteins), are molecules known to be involved in the regulation of numerous biological systems in which cell-to-cell interactions are particularly relevant. In the last years, we and other authors have demonstrated the importance of these molecules in the thymic functions and the T-cell development. In the present report, we review data on the effects of Ephs and ephrins in the functional maturation of both thymic epithelial microenvironment and thymocyte maturation as well as on their role in the lymphoid progenitor recruitment into the thymus.


Tipo de documento:Artículo
Palabras clave:thymocytes, thymic epithelium, Eph, ephrin, thymic cell seeding
Materias:Ciencias Biomédicas > Biología
Ciencias Biomédicas > Biología > Biología celular
Código ID:41965
Depositado:28 Mar 2017 14:27
Última Modificación:04 Abr 2017 09:48

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