Universidad Complutense de Madrid
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Correlation of brain levels of progesterone and dehydroepiandrosterone with neurological recovery after traumatic brain injury in female mice

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López Rodríguez, Ana Belén y Acaz Fonseca, Estefanía y Giatti, Silvia y Caruso, Donatella y Viveros, María Paz y Melcangi, Roberto C. y García Segura, Luis Miguel (2015) Correlation of brain levels of progesterone and dehydroepiandrosterone with neurological recovery after traumatic brain injury in female mice. Psychoneuroendocrinology, 56 . pp. 1-11. ISSN 0306-4530, ESSN: 1873-3360

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URL Oficial: http://www.sciencedirect.com/science/article/pii/S0306453015000803



Resumen

Traumatic brain injury (TBI) is an important cause of disability in humans. Neuroactive steroids, such as progesterone and dehydroepiandrosterone (DHEA), are neuroprotective in TBI models. However in order to design potential neuroprotective strategies based on neuroactive steroids it is important to determine whether its brain levels are altered by TBI. In this study we have used a weight-drop model of TBI in young adult female mice to determine the levels of neuroactive steroids in the brain and plasma at 24 h, 72 h and 2 weeks after injury. We have also analyzed whether the levels of neuroactive steroids after TBI correlated with the neurological score of the animals. TBI caused neurological deficit detectable at 24 and 72 h, which recovered by 2 weeks after injury. Brain levels of progesterone, tetrahydroprogesterone (THP), isopregnanolone and 17-estradiol were decreased 24 h, 72 h and 2 weeks after TBI. DHEA and brain testosterone levels presented a transient decrease at 24 h after lesion. Brain levels of progesterone and DHEA showed a positive correlation with neurological recovery. Plasma analyses showed that progesterone was decreased 72 h after lesion but, in contrast with brain progesterone, its levels did not correlate with neurological deficit. These findings indicate that TBI alters the levels of neuroactive steroids in the brain with independence of its plasma levels and suggest that the pharmacological increase in the brain of the levels of progesterone and DHEA may result in the improvement of neurological recovery after TBI.


Tipo de documento:Artículo
Palabras clave:Tetrahydroprogesterone; 17β-Estradiol; Dehydroepiandrosterone; Isopregnanolone; Progesterone; Testosterone
Materias:Ciencias Biomédicas > Biología > Fisiología animal
Ciencias Biomédicas > Biología > Neurociencias
Código ID:42645
Depositado:10 May 2017 09:39
Última Modificación:10 May 2017 11:52

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