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Signs and Symptoms of Dry Eye in Keratoconus Patients Before and After Intrastromal Corneal Rings Surgery

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Carracedo Rodríguez, Juan Gonzalo y Recchioni, Alberto y Alejandre Alba, Nicolás y Martín Gil, Alba y Batres Valderas, Laura y Jiménez Alfaro-Morote, Ignacio y Pintor, Jesús (2017) Signs and Symptoms of Dry Eye in Keratoconus Patients Before and After Intrastromal Corneal Rings Surgery. Current Eye Research, 42 (4). pp. 513-519. ISSN 0271-3683

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URL Oficial: http://dx.doi.org/10.1080/02713683.2016.1200098




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Purpose: Based on the relationship between keratoconus and dry eye, the aim of this study was to evaluate changes in signs and symptoms of dry eye in keratoconus patients before and after intrastromal corneal ring surgery.
Methods: Fifteen keratoconus patients were enrolled in Fundación Jiménez-Díaz of Madrid and University Clinic of Optometry of the Universidad Complutense de Madrid (Madrid, Spain). Tear break up time (TBUT), Schirmer test without anesthesia, corneal staining, diadenosine tetraphosphate (Ap4A) concentration, and ocular surface disease index (OSDI) were evaluated. Impression cytology combined with laser confocal microscopy was performed to evaluate goblet cell density, mucin cloud height (MCH), and cell layer thickness (CLT). All measurements were performed before (pre) surgery, 1 month (post) and 6 months after surgery (post6m).
Results: We found no statistical differences in time in Schirmer test, TBUT, and corneal staining. OSDI scores were 44.96  ±  8.65, 26.30 ± 6.79, and 19.31 ± 4.28 for (pre), (post), and (post6m) surgery, respectively (p < 0.001). Impression cytology showed a decrease in cell density at (post6m) compared with presurgery (47.36 ± 35.15 cells/mm2 and 84.88 ± 32.08 cells/mm2, respectively, p = 0.04). At post6m, the MCH increased compared with presurgery values (13.97 ± 4.26 µm and 6.77 ± 2.51 µm, respectively, p < 0.001). There was a statistically significant increase in CLT in time. Ap4A tear concentrations were lower post6m than presurgery (1.02  ±  0.65 and 2.56   ± 1.10  µM, respectively, p < 0.001). Conclusion: Intrastromal corneal ring surgery induces changes improving dry eye symptoms but no changes were found in signs of dry eye after surgery in keratoconus patients except for the MCH that increases drastically. More studies are needed to clarify the reason of its improvement.


Tipo de documento:Artículo
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Received 10 May 2015; Revised 11 May 2016; Accepted 7 Jun 2016; Published online: 22 Jul 2016

Palabras clave:3D impression cytology ; Dinucleotide ; Dry eye ; ICRS; Keratoconus
Materias:Ciencias Biomédicas > Medicina > Cirugía
Ciencias Biomédicas > Medicina > Oftalmología
Ciencias Biomédicas > Óptica y optometría > Óptica oftálmica
Ciencias Biomédicas > Óptica y optometría > Anatomía ocular
Código ID:44623
Depositado:14 Sep 2017 12:51
Última Modificación:15 Sep 2017 07:39

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