Universidad Complutense de Madrid
E-Prints Complutense

A versatile fluorescent molecular probe endowed with singlet oxygen generation under white-light photosensitization

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Durán Sampedro, Gonzalo y Epelde Elezcano, Nerea y Martínez Martínez, Virginia y Esnal Martínez, Ixone y Bañuelos Prieto, Jorge y García Moreno, Inmaculada y Rodríguez Agarrabeitia, Antonia y Moya Cerero, Santiago de la y Tabero Truchado, Andrea y Lázaro Carrillo, Ana y Villanueva Oroquieta, Ángeles y Ortíz García, María Josefa y López Arbeloa, Íñigo María (2017) A versatile fluorescent molecular probe endowed with singlet oxygen generation under white-light photosensitization. Dyes and Pigments, 142 . pp. 77-87. ISSN 0143-7208

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URL Oficial: http://dx.doi.org/10.1016/j.dyepig.2017.03.026



Resumen

Despite fluorescent photodynamic therapy (fluorescent-PDT) dyes are promising theranostic agents, current approaches unfortunately involve crucial shortcomings (such as, narrow absorption bands, high cost, low bio-compatibility and specificity, low dual efficiency) making difficult their clinical translation. Particularly, efficient fluorescent-PDT agents triggered under white-light, with potential application in topic solar treatments, are scarce. Here, we describe the rational development of a novel fluorescent-PDT molecular biomaterial based on BODIPY building blocks able to sustain, simultaneously, synthetic accessibility, high fluorescence and phototoxicity within a broad spectral window, biocompatibility, including low dark toxicity and high cell permeability with selective accumulation in lysosomes and, what is more important, excellent efficient activity triggered under white light. These all-in-one combined properties make the new dye a valuable ground platform for the development of future smarter theranostic agents.


Tipo de documento:Artículo
Información Adicional:

Received 30 January 2017, Revised 10 March 2017, Accepted 11 March 2017, Available online 12 March 2017.

Palabras clave:BODIPY dyes; Photosensitizers; Singlet oxygen; Theragnosis; White light; Photodynamic therapy
Materias:Ciencias > Química > Física
Ciencias > Química > Materiales
Ciencias > Química > Química orgánica
Ciencias Biomédicas > Biología > Bioquímica
Código ID:45025
Depositado:06 Oct 2017 07:36
Última Modificación:09 Oct 2017 07:47

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