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Ocular Surface Disease in Patients under Topical Treatment for Glaucoma



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Pérez Bartolomé, Francisco y Martínez de la Casa, Jose Maria y Arriola Villalobos, Pedro y Fernández Pérez, Cristina y Polo Llorens, Vicente y García Feijoo, Julián (2018) Ocular Surface Disease in Patients under Topical Treatment for Glaucoma. European Journal of Ophthalmology, 27 (6). pp. 694-704. ISSN 1120-6721

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URL Oficial: http://dx.doi.org/10.5301/ejo.5000977


Purpose: To examine the relationship between ocular surface disease (OSD) and topical antiglaucoma therapy.
Methods: A total of 211 eyes of 211 patients with open-angle glaucoma or ocular hypertension on topical medication were recruited over 10 months. Controls were 51 eyes of 51 healthy age- and sex-matched volunteers. In each patient, we recorded the intraocular pressure-lowering eyedrops used, the number of medications used, and daily and cumulative preservative concentrations (PC). Main outcome measures were fluorescein corneal staining score (Oxford scale), lower tear meniscus height (LTMH) (spectral-domain optical coherence tomography), noninvasive tear film breakup time (NI-TBUT) (Oculus Keratograph 5M), and OSD symptom questionnaire index (OSDI).
Results: Compared to controls, significantly higher OSDI (median [interquartile range] 10.24 [4.54-18.94] vs 2.5 [0-12.5]; p<0.001) and corneal staining (≥1: 64.93% vs 32.61%; p<0.001) scores were recorded in the medication group. The NI-TBUT and LTMH failed to vary between the groups (p>0.05). A higher daily PC was associated with a lower LTMH (R −0.142; p = 0.043). In the medication group, multivariate analysis identified correlations between benzalkonium chloride (BAK) (odds ratio [OR] 1.56) and BAK plus polyquaternium-containing drops (OR 5.09) or higher OSDI (OR 1.06) and abnormal corneal staining test results and between older age (mean ratio [MR] 1.05), longer treatment duration (MR 1.02), or corneal staining presence (MR 1.22) and a higher OSDI score.
Conclusions: Ocular surface disease was more prevalent in the medication group. The main factors impacting OSD were drops with preservatives, longer treatment duration, and older age.

Tipo de documento:Artículo
Información Adicional:

Article first published online: January 10, 2018
Issue published: November 8, 2017
Accepted: March 30, 2017

Palabras clave:Fourier-domain optical coherence tomography, Glaucoma medications, Keratograph 5M, Ocular surface disease
Materias:Ciencias Biomédicas > Medicina > Oftalmología
Ciencias Biomédicas > Farmacia > Medicamentos
Código ID:46256
Depositado:31 Ene 2018 09:09
Última Modificación:31 Ene 2018 09:09

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