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Beyond Traditional Hyperthermia. In vivo Cancer Treatment with Magnetic-Responsive Mesoporous Silica Nanocarriers

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Guisasola, Eduardo y Asin, Laura y Beola, Lillianne y De la Fuente, J. M. y Baeza, Alejandro y Vallet Regí, María (2018) Beyond Traditional Hyperthermia. In vivo Cancer Treatment with Magnetic-Responsive Mesoporous Silica Nanocarriers. ACS Applied Materials and Interfaces, 10 (15). pp. 12518-12525. ISSN 1944-8244

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URL Oficial: https://pubs.acs.org/




Resumen

In this study we present an innovation in the tumor treatment in vivo mediated by magnetic mesoporous silica nanoparticles (MMSNs). This device was built with iron oxide magnetic nanoparticles embedded in a mesoporous silica matrix and coated with an engineered thermoresponsive polymer. The magnetic nanoparticles act as internal heating sources under an alternating magnetic field (AMF) that increase the temperature of the surroundings, provoking the polymer transition and consequently the release of a drug trapped inside the silica pores. By a synergic effect between the intracellular hyperthermia and chemotherapy triggered by AMF application, significant tumor growth inhibition was achieved in 48 hours after treatment.
Furthermore, the small magnetic loading used in the experiments indicates that the treatment is carried out without a global temperature rise of the tissue, which avoids the problem of the necessity to employ large amounts of magnetic cores, as is common in current magnetic hyperthermia.


Tipo de documento:Artículo
Información Adicional:

RESEARCHER ID E-8300-2012 (Eduardo Guisasola Cal)
ORCID 0000-0002-2549-1745 (Eduardo Guisasola Cal)
RESEARCHER ID K-8193-2014 (Alejandro Baeza)
ORCID 0000-0002-9042-8865 (Alejandro Baeza)
RESEARCHER ID M-3378-2014 (María Vallet Regí)
ORCID 0000-0002-6104-4889 (María Vallet Regí)

Palabras clave:Hot spot, Stimuli-responsive, Drug delivery, Magnetic hyperthermia, Synergic therapy, Silica mesoporous nanoparticles, Thermosensitive polymer
Materias:Ciencias > Química > Materiales
Ciencias Biomédicas > Farmacia > Química inorgánica
Código ID:46996
Depositado:18 Abr 2018 08:42
Última Modificación:18 Abr 2018 08:54

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