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Can a Proper T-Cell Development Occur in an Altered Thymic Epithelium? Lessons From EphB-Deficient Thymi

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Muñoz, Juan José y García Ceca Hernández, Javier y Montero Herradón, Sara y Sánchez del Collado, Beatriz y Alfaro Sánchez, David y Zapata González, Agustín (2018) Can a Proper T-Cell Development Occur in an Altered Thymic Epithelium? Lessons From EphB-Deficient Thymi. Frontiers in Endocrinology, 9 (135). pp. 1-7. ISSN ESSN: 1664-2392

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URL Oficial: https://www.frontiersin.org/articles/10.3389/fendo.2018.00135/full



Resumen

For a long time, the effects of distinct Eph tyrosine kinase receptors and their ligands, ephrins on the structure, immunophenotype, and development of thymus and their main cell components, thymocytes (T) and thymic epithelial cells (TECs), have been studied. In recent years, the thymic phenotype of mutant mice deficient in several Ephs and ephrins B has been determined. Remarkably, thymic stroma in these animals exhibits important defects that appear early in ontogeny but little alterations in the proportions of distinct lymphoid cell populations. In the present manuscript, we summarize and extend these results discussing possible mechanisms governing phenotypical and functional thymocyte maturation in an absence of the critical T–TEC interactions, concluding that some signaling mediated by key molecules, such as MHCII, CD80, β5t, Aire, etc. could be sufficient to enable a proper maturation of thymocytes, independently of morphological alterations affecting thymic epithelium


Tipo de documento:Artículo
Palabras clave:Thymus; Thymocytes; Thymic epithelial cells; Eph; Ephrins
Materias:Ciencias Biomédicas > Medicina > Inmunología
Ciencias Biomédicas > Biología > Biología celular
Código ID:47646
Depositado:21 May 2018 10:03
Última Modificación:21 May 2018 10:06

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