Biblioteca de la Universidad Complutense de Madrid

Elicitation from virus-naive individuals of cytotoxic T lymphocytes directed against conserved HIV-1 epitopes

Impacto



Reche, Pedro A y Keskin, Derin B y Hussey, Rebecca E y Ancuta, Petronela y Gabuzda, Dana y Reinherz, Ellis L (2006) Elicitation from virus-naive individuals of cytotoxic T lymphocytes directed against conserved HIV-1 epitopes. Medical immunology (London, England), 5 . p. 1. ISSN 1476-9433

[img]
Vista previa
PDF
Creative Commons License
Esta obra está bajo una licencia de Creative Commons: Reconocimiento.

673kB

URL Oficial: http://www.medimmunol.com/content/5/1/1



Resumen

Cytotoxic T lymphocytes (CTL) protect against viruses including HIV-1. To avoid viral escape mutants that thwart immunity, we chose 25 CTL epitopes defined in the context of natural infection with functional and/or structural constraints that maintain sequence conservation. By combining HLA binding predictions with knowledge concerning HLA allele frequencies, a metric estimating population protection coverage (PPC) was computed and epitope pools assembled. Strikingly, only a minority of immunocompetent HIV-1 infected individuals responds to pools with PPC >95%. In contrast, virus-naive individuals uniformly expand IFNgamma producing cells and mount anti-HIV-1 cytolytic activity. This disparity suggests a vaccine design paradigm shift from infected to normal subjects.


Tipo de documento:Artículo
Materias:Ciencias Biomédicas > Medicina > Inmunología
Ciencias Biomédicas > Biología > Microbiología
Ciencias Biomédicas > Biología > Biología molecular
Ciencias > Informática > Bioinformática
Código ID:9327
Depositado:06 Aug 2009 08:39
Última Modificación:06 Oct 2014 11:09

Sólo personal del repositorio: página de control del artículo