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Elicitation from virus-naive individuals of cytotoxic T lymphocytes directed against conserved HIV-1 epitopes.

Reche, Pedro A and Keskin, Derin B and Hussey, Rebecca E and Ancuta, Petronela and Gabuzda, Dana and Reinherz, Ellis L (2006) Elicitation from virus-naive individuals of cytotoxic T lymphocytes directed against conserved HIV-1 epitopes. Medical immunology (London, England), 5 . p. 1. ISSN 1476-9433

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Abstract

Cytotoxic T lymphocytes (CTL) protect against viruses including HIV-1. To avoid viral escape mutants that thwart immunity, we chose 25 CTL epitopes defined in the context of natural infection with functional and/or structural constraints that maintain sequence conservation. By combining HLA binding predictions with knowledge concerning HLA allele frequencies, a metric estimating population protection coverage (PPC) was computed and epitope pools assembled. Strikingly, only a minority of immunocompetent HIV-1 infected individuals responds to pools with PPC >95%. In contrast, virus-naive individuals uniformly expand IFNgamma producing cells and mount anti-HIV-1 cytolytic activity. This disparity suggests a vaccine design paradigm shift from infected to normal subjects.


Item Type:Article
Subjects:Medical sciences > Medicine > Immunology
Medical sciences > Biology > Microbiology
Medical sciences > Biology > Molecular biology
Sciences > Computer science > Bioinformatics
ID Code:9327
Deposited On:06 Aug 2009 08:39
Last Modified:06 Feb 2014 08:23

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