Biblioteca de la Universidad Complutense de Madrid

Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP.

Impacto



Soumelis, Vassili y Reche, Pedro A y Kanzler, Holger y Yuan, Wei y Edward, Gina y Homey, Bernhart y Gilliet, Michel y Ho, Steve y Antonenko, Svetlana y Lauerma, Annti y Smith, Kathleen y Gorman, Daniel y Zurawski, Sandra M. y Abrams, Jon y Menon, Satish y McClanahan, Terri y Waal-Malefyt, Rene de y Bazan, Fernando y Kastelein, Robert A. y Liu, Yong-Jun (2002) Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP. Nature immunology, 3 (7). pp. 673-80. ISSN 1529-2908

[img] PDF
2MB


Resumen

Whether epithelial cells play a role in triggering the immune cascade leading to T helper 2 (T(H)2)-type allergic inflammation is not known. We show here that human thymic stromal lymphopoietin (TSLP) potently activated CD11c(+) dendritic cells (DCs) and induced production of the T(H)2-attracting chemokines TARC (thymus and activation-regulated chemokine; also known as CCL17) and MDC (macrophage-derived chemokine; CCL22). TSLP-activated DCs primed naïve T(H) cells to produce the proallergic cytokines interleukin 4 (IL-4), IL-5, IL-13 and tumor necrosis factor-alpha, while down-regulating IL-10 and interferon-gamma. TSLP was highly expressed by epithelial cells, especially keratinocytes from patients with atopic dermatitis. TSLP expression was associated with Langerhans cell migration and activation in situ. These findings shed new light on the function of human TSLP and the role played by epithelial cells and DCs in initiating allergic inflammation.


Tipo de documento:Artículo
Materias:Ciencias Biomédicas > Medicina > Inmunología
Ciencias Biomédicas > Biología > Biología molecular
Código ID:9340
Depositado:17 Aug 2009 08:10
Última Modificación:07 Jun 2011 08:39

Sólo personal del repositorio: página de control del artículo