Soumelis, Vassili and Reche, Pedro A and Kanzler, Holger and Yuan, Wei and Edward, Gina and Homey, Bernhart and Gilliet, Michel and Ho, Steve and Antonenko, Svetlana and Lauerma, Annti and Smith, Kathleen and Gorman, Daniel and Zurawski, Sandra M. and Abrams, Jon and Menon, Satish and McClanahan, Terri and Waal-Malefyt, Rene de and Bazan, Fernando and Kastelein, Robert A. and Liu, Yong-Jun (2002) Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP. Nature immunology, 3 (7). pp. 673-80. ISSN 1529-2908
Whether epithelial cells play a role in triggering the immune cascade leading to T helper 2 (T(H)2)-type allergic inflammation is not known. We show here that human thymic stromal lymphopoietin (TSLP) potently activated CD11c(+) dendritic cells (DCs) and induced production of the T(H)2-attracting chemokines TARC (thymus and activation-regulated chemokine; also known as CCL17) and MDC (macrophage-derived chemokine; CCL22). TSLP-activated DCs primed naïve T(H) cells to produce the proallergic cytokines interleukin 4 (IL-4), IL-5, IL-13 and tumor necrosis factor-alpha, while down-regulating IL-10 and interferon-gamma. TSLP was highly expressed by epithelial cells, especially keratinocytes from patients with atopic dermatitis. TSLP expression was associated with Langerhans cell migration and activation in situ. These findings shed new light on the function of human TSLP and the role played by epithelial cells and DCs in initiating allergic inflammation.
|Subjects:||Medical sciences > Medicine > Immunology|
Medical sciences > Biology > Molecular biology
|Deposited On:||17 Aug 2009 10:10|
|Last Modified:||07 Jun 2011 10:39|
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