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Propagation Failure Along Myelinated Nerves

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Carpio, Ana and Peral, I. (2011) Propagation Failure Along Myelinated Nerves. Journal of nonlinear science, 21 (4). pp. 499-520. ISSN 0938-8974

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Official URL: http://www.springerlink.com/content/r54558750281n137/fulltext.pdf



Abstract

Propagation of traveling pulses in the myelinated Hodgkin-Huxley model is studied. The nerve impulse is a traveling wave with two components. At the Ranvier nodes, it behaves as a discrete traveling pulse. Wave motion through the internodal regions is then driven by this traveling pulse. We give analytical characterizations of the parameter ranges for which nerve impulses fail to propagate by exploiting time scale separation and the active node approximation, which reduces the dynamics of infinite fibers to the evolution of a few nodes. Simple recipes to predict the speed of the impulses and the widths of their peaks are also given. Predictions are in good agreement with the information provided by numerical simulations.


Item Type:Article
Uncontrolled Keywords:Travelling waves · Propagation failure · Myelinated nerves · Reaction–diffusion systems
Subjects:Medical sciences > Biology > Biomathematics
Sciences > Mathematics > Differential equations
ID Code:14867
Deposited On:19 Apr 2012 08:13
Last Modified:12 Dec 2018 15:07

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