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Fungal extracellular ribotoxins as insecticidal agents

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Olombrada Sacristán, Miriam and Herrero Galán, Elías and Tello, Daniel and Oñaderra Sánchez, Mercedes and Gavilanes Franco, José G. and Martinez del Pozo, Álvaro and García Ortega, Lucía (2013) Fungal extracellular ribotoxins as insecticidal agents. Insect Biochemistry and Molecular Biology, 43 . pp. 39-46.

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Official URL: http://www.journals.elsevier.com/insect-biochemistry-and-molecular-biology/



Abstract

Fungal ribotoxins were discovered almost 50 years ago as extracellular ribonucleases (RNases) with antitumoral properties. However, the biological function of these toxic proteins has remained elusive. The discovery of the
ribotoxin HtA, produced by the invertebrates pathogen H. thompsonii, revived the old proposal that insecticidal activity would be their long searched function.
Unfortunately, HtA is rather singular among all ribotoxins known in terms of sequence and structure similarities. Thus, it was intriguing to answer the question of whether HtA is just an exception or, on the contrary, the
paradigmatic example of the ribotoxins function. The work presented uses HtA and -sarcin, the most representative member of the ribotoxins family, to show their strong toxic action against insect larvae and cells.


Item Type:Article
Uncontrolled Keywords:Fungal ribotoxin; Ribonuclease; Ribosome inactivation; Insecticide
Subjects:Sciences > Chemistry > Biochemistry
ID Code:18061
Deposited On:12 Feb 2013 09:22
Last Modified:12 Feb 2013 09:22

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