Universidad Complutense de Madrid
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Estradiol impairs the Th17 immune response against Candida albicans

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Relloso, Miguel y Aragoneses-Fenoll, Laura y Lasarte, Sandra y Bourgeois, Christelle y Romera, Gema y Kuchler, Karl y Corbí, Angel L. y Muñoz-Fernández, M. Angeles y Nombela, César y Rodríguez-Fernández, José L. y Díez-Orejas, Rosalia (2012) Estradiol impairs the Th17 immune response against Candida albicans. Journal of leukocyte biology, 91 (1). pp. 159-65. ISSN 1938-3673

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URL Oficial: http://www.jleukbio.org



Resumen

Candida albicans is a commensal opportunistic pathogen that is also a member of gastrointestinal and reproductive tract microbiota. Exogenous factors, such as oral contraceptives, hormone replacement therapy, and estradiol, may affect susceptibility to Candida infection, although the mechanisms involved in this process have not been elucidated. We used a systemic candidiasis model to investigate how estradiol confers susceptibility to infection. We report that estradiol increases mouse susceptibility to systemic candidiasis, as in vivo and ex vivo estradiol-treated DCs were less efficient at up-regulating antigen-presenting machinery, pathogen killing, migration, IL-23 production, and triggering of the Th17 immune response. Based on these results, we propose that estradiol impairs DC function, thus explaining the increased susceptibility to infection during estrus.


Tipo de documento:Artículo
Palabras clave:Microbiología
Materias:Ciencias Biomédicas > Farmacia > Microbiología
Código ID:21947
Depositado:25 Jun 2015 12:32
Última Modificación:01 Jul 2015 11:49

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