Universidad Complutense de Madrid
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Mathematical modeling for protein folding devices. Applications to high pressure processing and microfluidic mixers.

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Bello Rivas, Juan and Infante del Río, Juan Antonio and Ivorra, Benjamin and López Redondo, Juana and Martínez Ortigosa, Pilar and Ramos del Olmo, Ángel Manuel and Rey Cabezas, Jose María and Smith, Nadia A. S (2010) Mathematical modeling for protein folding devices. Applications to high pressure processing and microfluidic mixers. In Proceedings of the 2nd International Conference on Engineering Optimization: Book of Abstracts and CD-ROM Proceedings. Associação Portuguesa de Mecânica Teórica, Aplicada e Computacional, Lisboa. ISBN 978-989-9626430

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Official URL: http://www.dem.ist.utl.pt/engopt2010/Book_and_CD/Papers_CD_Final_Version/html/authors/i/Ivorra_Benjamin.html




Abstract

In this paper, we consider two particular devices used for protein folding. The first one is a microfluidic mixer that perform a folding process by mixing a protein solution with a solvent. We are interested in minimizing its mixing time by choosing suitable shape and flow conditions. The second one is related to food processing and we focus on the modeling and simulation of the temperature evolution inside a high pressure food treatment device. Some of the effects of such treatments is to unfold, and thus inactivate, certain enzymes inside the food sample. The behavior and stability of the proposed model is checked by numerical examples. Furthermore, a simplified version of this model is presented and compared in terms of accuracy and computational time.


Item Type:Book Section
Additional Information:

EngOpt 2010 (2nd International Conference On Engineering Optimization. Lisbon, 6-9 September 2010)

Uncontrolled Keywords:High-Pressure; Protein folding; Mathematical modeling; Global Optimization.
Subjects:Sciences > Physics > Mathematical physics
ID Code:23358
Deposited On:25 Oct 2013 10:44
Last Modified:12 Dec 2018 15:07

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