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Analysis of the electric field induced forces in erythrocyte membrane pores using a realistic cell model

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Sebastián Franco, José Luis and Muñoz San Martín, Sagrario and Sancho Ruíz, Miguel and Miranda Pantoja, José Miguel (2006) Analysis of the electric field induced forces in erythrocyte membrane pores using a realistic cell model. Physics in Medicine and Biology, 51 (23). pp. 6213-6224. ISSN 0031-9155

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Official URL: http://dx.doi.org/10.1088/0031-9155/51/23/019


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Abstract

We calculate the induced electric stress forces on transient hydrophobic pores in the membrane of an erythrocyte exposed to an electric field. For this purpose, we use a finite element numerical technique and a realistic shape for the biconcave erythrocyte represented by a set of parametric equations in terms of Jacobi elliptic functions. The results clearly show that the electrical forces on the base and sidewalls of the pore favour the opening of the pore. A comparison of the force densities obtained for an unstretched flat membrane and for the realistic erythrocyte model shows that the thinning and curvature of the membrane cannot be neglected. We also show that the pore deformation depends strongly on the orientation of the pore with respect to the external field, and in particular is very small when the field is tangent to the membrane surface.


Item Type:Article
Additional Information:

© IOP Publishing Ltd. This work was supported by the Comunidad de Madrid under Grant number: PR45/05-14166.

Uncontrolled Keywords:Asymptotic Model, Lipid-Bilayers, Single-Cell, Electroporation, Voltage, Radiation, Breakdown, Hemolysis, Exposure, Tissues.
Subjects:Sciences > Physics > Electronics
Sciences > Physics > Electricity
ID Code:23882
Deposited On:11 Dec 2013 13:39
Last Modified:10 Dec 2018 14:58

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