Publication: A study of the electric field distribution in erythrocyte and rod shape cells from direct RF exposure
Loading...
Official URL
Full text at PDC
Publication Date
2003-06-07
Advisors (or tutors)
Editors
Journal Title
Journal ISSN
Volume Title
Publisher
IOP Publishing Ltd
Citations
Exportar
Abstract
This paper shows the importance of using realistic cell shapes with the proper geometry and orientation to study the mechanisms of direct cellular effects from radiofrequency (RF) exposure. For this purpose, the electric field distribution within erythrocyte, rod and ellipsoidal cell models is calculated by using a finite element technique with adaptive meshing. The three cell models are exposed to linearly polarized electromagnetic plane waves of frequencies 900 and 2450 MHz. The results show that the amplification of the electric field within the membrane of the erythrocyte shape cell is more significant than that observed in other cell geometries. The results obtained show the dependence of the induced electric field distribution on frequency, electrical properties of membrane and cytoplasm and the orientation of the cell with respect to the applied field. The analysis of the transition of an erythrocyte shape to an ellipsoidal one shows that a uniformly shelled ellipsoid model is a rough approximation if a precise simulation of bioeffects in cells is desired.
Description
© IOP Publishing Ltd. This work has been sponsored by the Ministerio de Ciencia y Tecnologia, project FIT-070000-2002-135.
UCM subjects
Unesco subjects
Keywords
Citation
1) Becache, E., Joly, P., 2001, On the analysis of Berenger’s perfectly matched layers for Maxwell equations INRIA, Report No 4164.
2) Fricke, H., 1925, The electric capacity of suspensions with special reference to blood, J. Gen. Physiol., 9, 137–52.
3) Fuhr, G., Zimmermann, U., Shirley, S.G., 1996, Cell Motion in Time Varying Fields: Principles and Potential in Electromanipulation of Cells, ed. U. Zimmermann, G.A. Neil (Boca Raton, FL: CRC Press) pp 259–328.
4) Gabriel, S., Lau, R.W., Gabriel, C., 1996, The dielectric properties of biological tissues: III. Parametric models for the dielectric spectrum of tissues, Phys. Med. Biol., 41, 2271–93.
5) Gimsa, J., Wachner, D., 2001, Analytical description of the transmembrane voltage induced on arbitrarily oriented ellipsoidal and cylindrical cells, Biophys. J., 81, 1888–96.
6) Huang, J.P., Yu, K.W., 2002, Dielectric behaviour of oblate spheroidal particles: application to erythrocytes suspensions, Commun. Theor. Phys., 1, 82–7.
7) Jin, J., 1993, The Finite Element Method in Electromagnetics (New York: Wiley).
8) Liu, L.M., Cleary, S.F., 1995, Absorbed energy distribution from radiofrequency electromagnetic radiation in mammalian cell model: effect of membrane-bound water, Bioelectromagnetics, 16, 160–71.
9) Miller, R.D., Jones, T.B., 1993, Electro orientation of ellipsoidal erythrocytes, Biophys. J., 64, 1588–95.
10) Morse, P.M., Feshbach, H., 1953, Methods of Theoretical Physics (New York: McGraw-Hill).
11) Sebastián, J.L., Muñoz, S., Sancho, M., Miranda, J.M., 2001, Analysis of the influence of the cell geometry orientation and cell proximity effects on the electric field distribution from direct RF exposure, Phys. Med. Biol., 46, 213–25.
12) Thuery, J., 1992, Microwaves: Industrial, Scientific and Medical Applications, ed. Edward, H. Grant (Artech House).