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Early Stages of Bone Fracture Healing: Formation of a Fibrin–Collagen Scaffold in the Fracture Hematoma

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Herrero, Miguel A. and Oleaga Apadula, Gerardo Enrique and Echeverri, L.F. and López, J. M. (2014) Early Stages of Bone Fracture Healing: Formation of a Fibrin–Collagen Scaffold in the Fracture Hematoma. Bulletin of mathematical biology, 77 (1). pp. 156-183. ISSN 0092-8240

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Official URL: http://link.springer.com/article/10.1007/s11538-014-0055-3



Abstract

This work is concerned with the sequence of events taking place during the first stages of bone fracture healing, from bone breakup until the formation of early fibrous callus (EFC). The latter provides a scaffold over which subsequent remodeling processes will eventually result in successful bone repair. Specifically, some mathematical models are proposed to estimate the time required for (1) the formation immediately after fracture of a fibrin clot, described in terms of a phase transition in a polymerization process, and (2) the onset of EFC which is produced when fibroblasts arising from differentiation of chemotactically recruited mesenchymal stem cells remodel a previous fibrin clot by releasing a collagen matrix over it. An attempt has been made to keep models as simple as possible, so that a explicit dependence of the estimates obtained on relevant biochemical parameters involved is obtained.


Item Type:Article
Uncontrolled Keywords:Mathematical modeling of bone healing; Fibrin polymerization; Chemotaxis; Early callus formation; Moving differentiation fronts
Subjects:Sciences > Mathematics
ID Code:29000
Deposited On:04 Mar 2015 11:14
Last Modified:12 Dec 2018 15:06

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