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Vasoactive intestinal peptide in early spondyloarthritis: low serum levels as a potential biomarker for disease severity

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Seoane, Iria V. and Tomero, Eva and Martínez, Carmen and Garcia-Vicuña, Rosario and Juarranz Moratilla, Yasmina and Lamana, Amalia and Ocón, Elena and Ortiz, Ana M. and Gómez-León, Nieves and González-Álvaro, Isidoro and Pérez-Gomáriz, Rosa (2015) Vasoactive intestinal peptide in early spondyloarthritis: low serum levels as a potential biomarker for disease severity. Journal of Molecular Neuroscience . ISSN 0895-8696

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Official URL: http://link.springer.com/article/10.1007/s12031-015-0517-6



Abstract

Spondyloarthritis (SpA) is a family of inflammatory
diseases sharing clinical, genetic, and radiological features.
While crucial for tailoring early interventions, validated prognostic
biomarkers are scarce in SpA. We analyze the correlation
between serum levels of vasoactive intestinal peptide
(VIP) and disease activity/severity in patients with early
chronic inflammatory back pain. The study population comprised
54 patients enrolled in our early chronic inflammatory
back pain register. We collected demographic information,
clinical data, laboratory data, and imaging findings. VIP levels
were measured by enzyme immunoassay in serum samples
from 162 visits. The association between independent variables
and VIP levels was analyzed using longitudinal multivariate
analysis nested by patient and visit. No significant
differences were observed in VIP levels between these two
groups. Lower levels of VIP were significantly associated
with a higher Bath Ankylosing Spondylitis Disease Activity
Index (BASFI) score, presence of bone edema in magnetic
resonance imaging (MRI) scan, and lower hemoglobin levels.
Coexistence of cutaneous psoriasis was independently associated
with lower VIP levels, and similar trend was observed for
enthesitis.We conclude that SpA patients with low serum VIP
levels had worse 2-year disease outcome, suggesting that


Item Type:Article
Uncontrolled Keywords:Neuroimmunomodulation, Spondyloarthritis, Vasoactive intestinal peptide, Prognosis biomarker, Bath ankylosing spondylitis disease activity index
Subjects:Medical sciences > Biology > Biochemistry
Medical sciences > Biology > Neurosciences
ID Code:29445
Deposited On:13 Apr 2015 15:27
Last Modified:13 Apr 2015 15:27

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