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Differential growth of wrinkled biofilms

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Espeso, D.R. and Carpio, Ana and Einarsson, B. (2015) Differential growth of wrinkled biofilms. Physical Review E, 91 (2). ISSN 1539-3755

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Official URL: http://journals.aps.org/pre/pdf/10.1103/PhysRevE.91.022710



Abstract

Biofilms are antibiotic-resistant bacterial aggregates that grow on moist surfaces and can trigger hospital-acquired infections. They provide a classical example in biology where the dynamics of cellular communities may be observed and studied. Gene expression regulates cell division and differentiation, which affect the biofilm architecture. Mechanical and chemical processes shape the resulting structure. We gain insight into the interplay between cellular and mechanical processes during biofilm development on air-agar interfaces by means of a hybrid model. Cellular behavior is governed by stochastic rules informed by a cascade of concentration fields for nutrients, waste and autoinducers. Cellular differentiation and death alter the structure and the mechanical properties of the biofilm, which is deformed according to Foppl-Von Karman equations informed by cellular processes and the interaction with the substratum. Stiffness gradients due to growth and swelling produce wrinkle branching. We are able to reproduce wrinkled structures often formed by biofilms on air-agar interfaces, as well as spatial distributions of differentiated cells commonly observed with B. subtilis.


Item Type:Article
Uncontrolled Keywords:Biological Physics ; Soft Condensed Matter ; Adaptation and Self-Organizing Systems ; Cellular Automata and Lattice Gases ; Tissues and Organs
Subjects:Sciences > Mathematics
ID Code:29579
Deposited On:15 Apr 2015 10:40
Last Modified:12 Dec 2018 15:06

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