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Brain oscillatory complexity across the life span

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Fernández, Alberto and Zuluaga Arias, Pilar and Abásolo, Daniel and Gómez, Carlos and Serra González, Anahí María and Méndez, María Andreína and Hornero, Roberto (2012) Brain oscillatory complexity across the life span. Clinical neurophysiology, 123 (11). pp. 2154-2162. ISSN 1388-2457

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Official URL: http://www.sciencedirect.com/science/article/pii/S138824571200332X




Abstract

Objective
Considering the increasing use of complexity estimates in neuropsychiatric populations, a normative study is critical to define the ‘normal’ behaviour of brain oscillatory complexity across the life span.

Method
This study examines changes in resting-state magnetoencephalogram (MEG) complexity – quantified with the Lempel–Ziv complexity (LZC) algorithm – due to age and gender in a large sample of 222 (100 males/122 females) healthy participants with ages ranging from 7 to 84 years.

Results
A significant quadratic (curvilinear) relationship (p < 0.05) between age and complexity was found, with LZC maxima being reached by the sixth decade of life. Once that peak was crossed, complexity values slowly decreased until late senescence. Females exhibited higher LZC values than males, with significant differences in the anterior, central and posterior regions (p < 0.05).

Conclusions
These results suggest that the evolution of brain oscillatory complexity across the life span might be considered a new illustration of a ‘normal’ physiological rhythm.

Significance
Previous and forthcoming clinical studies using complexity estimates might be interpreted from a more complete and dynamical perspective. Pathologies not only cause an ‘abnormal’ increase or decrease of complexity values but they actually ‘break’ the ‘normal’ pattern of oscillatory complexity evolution as a function of age.


Item Type:Article
Uncontrolled Keywords:Life Span, Ageing, Complexity, Brain Development, White Matter Development
Subjects:Sciences > Mathematics > Applied statistics
Medical sciences > Biology
ID Code:30518
Deposited On:29 May 2015 08:51
Last Modified:13 Jul 2015 11:38

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