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Complexity Analysis of Spontaneous Brain Activity in Attention-Deficit/Hyperactivity Disorder: Diagnostic Implications

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Fernández, A. and Quintero, J. and Hornero, J. and Zuluaga Arias, Pilar and Navas, M. and Gómez, C. and Escudero, J. and García Campos, N. and Biederman, J. and Ortiz, T. (2009) Complexity Analysis of Spontaneous Brain Activity in Attention-Deficit/Hyperactivity Disorder: Diagnostic Implications. Biological psychiatry, 65 (7). pp. 571-577. ISSN 0006-3223

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Official URL: http://www.sciencedirect.com/science/article/pii/S000632230801408X




Abstract

Background: Attention-deficit/hyperactivity disorder (ADHD) is defined as the most common neurobehavioral disorder of childhood, but an objective diagnostic test is not available yet to date. Neurophychological, neuroimaging, and neurophysiological research offer ample evidence of brain and behavioral dysfunctions in ADHD, but these findings have not been useful as a diagnostic test. Methods: Whole-head magnetoencephalographic recordings were obtained from 14 diagnosed ADHD patients and 14 healthy children during resting conditions. Lempel-Ziv complexity (LZC) values were obtained for each channel and child and averaged in five sensor groups: anterior, central, left lateral, right lateral, and posterior. Results: Lempel-Ziv complexity scores were significantly higher in control subjects, with the maximum value in anterior region. Combining age and anterior complexity values allowed the correct classification of ADHD patients and control subjects with a 93% sensitivity and 79% specificity. Control subjects showed an age-related monotonic increase of LZC scores in all sensor groups, while children with ADHD exhibited a nonsignificant tendency toward decreased LZC scores. The age-related divergence resulted in a 100% specificity in children older than 9 years. Conclusions: Results support the role of a frontal hypoactivity in the diagnosis of ADHD. Moreover, the age-related divergence of complexity scores between ADHD patients and control subjects might reflect distinctive developmental trajectories. This interpretation of our results is in agreement with recent investigations reporting a delay of cortical maturation in the prefrontal cortex


Item Type:Article
Uncontrolled Keywords:Attention-deficit/hyperactivity disorder; brain maturation; complexity; maturational delay; MEG; nonlinear analysis. EMTREE medical terms: age; analysis; article; attention deficit disorder; brain maturation; child; clinical article; controlled study; human; lempel ziv complexity analysis; magnetoencephalography; male; prefrontal cortex; priority journal; school child; scoring system; sensitivity and specificity; spontaneous brain activity MeSH: Aging; Attention Deficit Disorder with Hyperactivity; Brain; Case-Control Studies; Child; Humans; Magnetoencephalography; Male; Sensitivity and Specificity
Subjects:Sciences > Mathematics > Applied statistics
Medical sciences > Biology
ID Code:30571
Deposited On:01 Jun 2015 10:44
Last Modified:01 Jun 2015 10:44

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