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Magnetoencephalographic parietal δ dipole density in mild cognitive impairment: Preliminary results of a method to estimate the risk of developing Alzheimer disease

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Fernández, Alberto and Turrero, Agustín and Zuluaga Arias, Pilar and Gil, Pedro and Maestú, Fernando and Campo, Pablo and Ortiz, Tomás (2006) Magnetoencephalographic parietal δ dipole density in mild cognitive impairment: Preliminary results of a method to estimate the risk of developing Alzheimer disease. Archives of neurology, 63 (3). pp. 427-430. ISSN 0003-9942

Official URL: http://archneur.jamanetwork.com/article.aspx?articleid=790798



Abstract

Background: Subjects with mild cognitive impairment (MCI) are at a higher risk of experiencing Alzheimer disease (AD). Magnetoencephalographic temporoparietal dipole densities of low-frequency activity are good predictors of individuals' cognitive status, and might be a useful tool to investigate the conversion from MCI to AD.

Objective: To investigate the role of low-frequency dipole densities as predictors of the risk of developing AD.

Design: Whole-head magnetoencephalographic recordings were obtained from 19 probable AD patients, 17 MCI patients, and 17 healthy control subjects. The generators of focal magnetic slow waves were located using a single moving dipole model.

Results: Left parietal δ dipole density permitted a reliable classification of AD and MCI patients. The MCI patients were divided into 2 groups based on the median left parietal δ dipole density, and were followed up for 2 years. The estimated relative risk of conversion to AD was increased by 350% in those MCI patients with high left parietal δ dipole density scores.

Conclusions: Results confirmed the important role of parietal δ dipole density in the evaluation of AD and MCI. A magnetoencephalographic-based assessment of AD and MCI patients might be considered a useful clinical test in the near future.


Item Type:Article
Uncontrolled Keywords:EMTREE medical terms: aged; Alzheimer disease; article; clinical article; cognitive defect; controlled study; density; dipole; disease classification; follow up; health status; human; magnetoencephalography; mild cognitive impairment; prediction; priority journal; risk factor; scoring system; waveform MeSH: Aged; Aged, 80 and over; Alzheimer Disease; Brain Mapping; Case-Control Studies; Cognition Disorders; Female; Follow-Up Studies; Humans; Logistic Models; Magnetoencephalography; Male; Mental Status Schedule; Neuropsychological Tests; Parietal Lobe; Risk
Subjects:Sciences > Mathematics > Applied statistics
Medical sciences > Biology
ID Code:30692
Deposited On:05 Jun 2015 11:46
Last Modified:05 Jun 2015 11:46

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