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Dipole density of low-frequency and spike magnetic activity: A reliable procedure in presurgical evaluation of temporal lobe epilepsy

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Fernández, Alberto and de Sola, Rafael G. and Amo, Carlos and Turrero, Agustín and Zuluaga Arias, Pilar and Maestú, Fernando and Campo, Pablo and Ortiz, Tomás (2004) Dipole density of low-frequency and spike magnetic activity: A reliable procedure in presurgical evaluation of temporal lobe epilepsy. Journal of Clinical Neurophysiology, 21 (4). pp. 254-266. ISSN 0736-0258

Official URL: http://journals.lww.com/clinicalneurophys/Abstract/2004/07000/Dipole_Density_of_Low_Frequency_and_Spike_Magnetic.4.aspx


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Abstract

Conventional visual analysis and dipole density analysis of magnetoencephalographic data for both spike and low-frequency magnetic activity were compared for presurgical evaluation in temporal lobe epilepsy (TLE) in a sample of 26 drug-resistant operated TLE patients. A series of logistic regression analyses were performed. Dipole density sensitivity was superior to visual localization analysis. Three separated logistic models were calculated for interictal spikes, low-frequency magnetic activity, and the combination of both measures. A combined interictal spike/low-frequency magnetic activity model predicted correctly the operated temporal lobe in all patients. Clear-cut criteria for the probability model are proposed that are valid for 92.3% of cases in the sample. The quantitative approach proposed by this study is an evidence-based model for presurgical evaluation of temporal lobe epilepsy, which improves previous magnetoencephalographic investigations and establishes working clinical criteria for patient evaluation in TLE.


Item Type:Article
Uncontrolled Keywords:Interictal; Low-frequency magnetic activity; Magnetoencephalography; Temporal lobe epilepsy EMTREE medical terms: adolescent; adult; article; clinical article; comparative study; controlled study; dipole; evidence based medicine; female; human; logistic regression analysis; magnetism; magnetoencephalography; male; preoperative evaluation; spike; statistical model; temporal lobe epilepsy; visual orientation MeSH: Adolescent; Adult; Electroencephalography; Epilepsy, Temporal Lobe; Humans; Logistic Models; Magnetoencephalography; Male; Middle Aged; Models, Statistical; Preoperative Care
Subjects:Sciences > Mathematics > Applied statistics
Medical sciences > Biology
ID Code:30718
Deposited On:08 Jun 2015 08:33
Last Modified:08 Jun 2015 08:33

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