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Lempel-Ziv complexity in schizophrenia: A MEG study

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Fernández, A. and López-Ibor, M.I. and Turrero, Agustín and Santos, J. M. and Morón, M.D. and Hornero, R. and Gómez, C. and Méndez, M.A. and Ortiz, T. and López-Ibor, J.J. (2011) Lempel-Ziv complexity in schizophrenia: A MEG study. Clinical neurophysiology, 122 (11). pp. 2227-2235. ISSN 1388-2457

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Official URL: http://www.sciencedirect.com/science/article/pii/S1388245711002689




Abstract

Objective: The neurodevelopmental-neurodegenerative debate is a basic issue in the field of the neuropathological basis of schizophrenia (SCH). Neurophysiological techniques have been scarcely involved in such debate, but nonlinear analysis methods may contribute to it. Methods: Fifteen patients (age range 23-42. years) matching DSM IV-TR criteria for SCH, and 15 sex- and age-matched control subjects (age range 23-42. years) underwent a resting-state magnetoencephalographic evaluation and Lempel-Ziv complexity (LZC) scores were calculated. Results: Regression analyses indicated that LZC values were strongly dependent on age. Complexity scores increased as a function of age in controls, while SCH patients exhibited a progressive reduction of LZC values. A logistic model including LZC scores, age and the interaction of both variables allowed the classification of patients and controls with high sensitivity and specificity. Conclusions: Results demonstrated that SCH patients failed to follow the " normal" process of complexity increase as a function of age. In addition, SCH patients exhibited a significant reduction of complexity scores as a function of age, thus paralleling the pattern observed in neurodegenerative diseases. Significance: Our results support the notion of a progressive defect in SCH, which does not contradict the existence of a basic neurodevelopmental alteration.


Item Type:Article
Uncontrolled Keywords:Lempel-Ziv complexity; Magnetoencephalography; Neurodegenerative; Neurodevelopmental; Schizophrenia. EMTREE medical terms: adult; age; article; clinical article; controlled study; correlation analysis; female; human; lempel ziv complexity score; logistic regression analysis; magnetoencephalography; male; patient coding; priority journal; schizophrenia; scoring system; sensitivity and specificity. MeSH: Adult; Aging; Cerebral Cortex; Cognition Disorders; Disease Progression; Female; Humans; Magnetoencephalography; Male; Schizophrenia; Schizophrenic Psychology; Signal Processing, Computer-Assisted; Young Adult
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ID Code:30852
Deposited On:12 Jun 2015 08:33
Last Modified:13 Jul 2015 11:38

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