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Complexity analysis of spontaneous brain activity in alzheimer disease and mild cognitive impairment: An MEG study

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Fernández, Alberto and Hornero, Roberto and Gómez, Carlos and Turrero, Agustín and Gil Gregorio, Pedro and Matías Santos, Juan and Ortiz, Tomás (2010) Complexity analysis of spontaneous brain activity in alzheimer disease and mild cognitive impairment: An MEG study. Alzheimer Disease & Associated Disorders, 24 (2). pp. 182-189. ISSN 0893-0341

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Official URL: http://journals.lww.com/alzheimerjournal/Abstract/2010/04000/Complexity_Analysis_of_Spontaneous_Brain_Activity.12.aspx




Abstract

Nonlinear analyses have shown that Alzheimer disease (AD) patients' brain activity is characterized by a reduced complexity and connectivity. The aim of this study is to define complexity patterns of mild cognitive impairment (MCI) patients. Whole-head magnetoencephalography recordings were obtained from 18 diagnosed AD patients, 18 MCI patients, and 18 healthy controls during resting conditions. Lempel-Ziv complexity (LZC) values were calculated. MCI patients exhibited intermediary LZC scores between AD patients and controls. A combination of age and posterior LZC scores allowed ADs-MCIs discrimination with 94.4% sensitivity and specificity, whereas no LZC score allowed MCIs---controls discrimination. AD patients and controls showed a parallel tendency to diminished LZC scores as a function of age, but MCI patients did not exhibit such “normal” tendency. Accordingly, anterior LZC scores allowed MCIs-controls discrimination for subjects below 75 years. MCIs exhibited a qualitatively distinct relationship between aging and complexity reduction, with scores higher than controls in older individuals. This fact might be considered a new example of compensatory mechanism in MCI before fully established dementia.


Item Type:Article
Uncontrolled Keywords:Aging; Compensatory mechanism; Complexity; Dementia; Mild cognitive impairment; Nonlinear analysis. EMTREE medical terms: age; aged; aging; Alzheimer disease; article; clinical article; controlled study; female; human; magnetoencephalography; male; mild cognitive impairment; mini mental state examination; neuropsychological test; nonlinear system; priority journal; qualitative analysis; rest; scoring system; sensitivity and specificity; Wechsler Memory Scale; Wisconsin Card Sorting Test. MeSH: Aged; Aging; Alzheimer Disease; Brain; Cognition Disorders; Female; Humans; Magnetoencephalography; Male; Sensitivity and Specificity.
Subjects:Sciences > Mathematics > Applied statistics
Medical sciences > Biology
ID Code:30887
Deposited On:15 Jun 2015 08:02
Last Modified:15 Jun 2015 08:02

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