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A novel zwitterionic bioceramic with dual antibacterial capability

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Colilla, Montserrat and Martínez Carmona, Marina and Sánchez-Salcedo, Sandra and Ruiz González, M. Luisa and González Calbet, José M. and Vallet Regí, María (2014) A novel zwitterionic bioceramic with dual antibacterial capability. Journal of Materials Chemistry B, 2 (34). pp. 5639-5651. ISSN 2050-750X

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Official URL: http://dx.doi.org/10.1039/c4tb00690a



Abstract

A novel zwitterionic SBA-15 type bioceramic with dual antibacterial capability has been synthesized. The cocondensation route has been employed to functionalize SBA-15 with primary and secondary amine groups. The resulting material exhibits textural and nanostructural properties comparable to those of pure silica SBA-15, as confirmed by XRD, HR-TEM and N2 adsorption porosimetry. The presence of –NH3 4/–SiO. and >NH2 4/–SiO. zwitterionic pairs on the material surface is evidenced by FTIR and 1H / 13C CP/MAS solid state NMR. The homogeneous distribution of this zwitterionic pairs agrees with the results derived from STEM-EDS studies. z-Potential measurements indicate that the zwitterionic nature of this material is preserved at the physiological pH of 7.4. In vitro bacterial assays using S. aureus demonstrate that the zwitterionic material is capable of inhibiting 99.9% of the bacterial adhesion compared to pure silica SBA-15. Moreover, cephalexin loading and delivery assays indicate that the zwitterionic sample is capable of releasing antibiotic molecules over long time periods. This dual antibacterial capability, i.e. antibiofouling and bactericidal, opens up promising expectations for the treatment of bone implant infections.


Item Type:Article
Uncontrolled Keywords:Materiales biomedicos, Bactericidas
Palabras clave (otros idiomas):Silica
Subjects:Sciences > Chemistry > Chemistry, Inorganic
ID Code:30902
Deposited On:29 Jun 2015 09:23
Last Modified:30 Jan 2017 14:56

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