Publication: Towards the development of smart 3D “gated scaffolds” for on-command delivery
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Publication Date
2014
Authors
Mas, Núria
Polo, Lorena
Aznar, Elena
Sancenón, Félix
Marcos Vega, M. Dolores
Baeza, Alejandro
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Publisher
Wiley-VCH
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Abstract
A new approach towards the design of “gated scaffolds” based on the combination of capped mesoporous silica nanoparticles (MSNs) with porous biomaterials is reported. Using this approach, a 3D gelatin-based scaffold able to selectively deliver cargo in the presence of an APase enzyme is prepared and tested. This new design opens up the possibility of developing new smart biomaterials with advanced drug-delivery features.