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Tuning dual-drug release from composite scaffolds for bone 2 regeneration

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Paris, J.L. and Román, M. and Cabañas Criado, Maria Victoria and Vallet Regí, María and Manzano García, Miguel (2015) Tuning dual-drug release from composite scaffolds for bone 2 regeneration. International Journal of Pharmaceutics . ISSN Planta Medica (In Press)

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Official URL: http://dx.doi.org/10.1016/j.ijpharm.2015.03.048




Abstract

This work presents the tuning of drug-loaded scaffolds for bone regeneration as dual-drug delivery systems. Two therapeutic substances, zoledronic acid (anti-osteoporotic drug) and ibuprofen (antiinflammatory drug) were successfully incorporated in a controlled mannerinto three dimensional designed porous scaffolds of apatite/agarose composite. A high-performance liquid chromatography method was optimized to separate and simultaneously quantify the two drugs released from the dualdrug codelivery system. The multifunctional porous scaffolds fabricated show a very rapid delivery of anti-inflammatory (interesting to reduce inflammation after implantation), whereas the antiosteoporotic drug showed sustained release behaviour (important to promote bone regeneration). Since ibuprofen release was faster than desired, this drug was encapsulated in chitosan spheres which were then incorporated into the scaffolds, obtaining a release profile suitable for clinical application. The results obtained open the possibility to simultaneously incorporate two or more drugs to an osseous implant in a controlled way improving it for bone healing application.


Item Type:Article
Uncontrolled Keywords:Dual-drug delivery system, Designed porous scaffold, Ibuprofen, Zoledronic acid, Co-delivery release, Tissue engineering
Subjects:Sciences > Chemistry > Chemistry, Inorganic
ID Code:30922
Deposited On:14 Jul 2015 10:54
Last Modified:20 Jul 2015 09:31

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