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Ophthalmologic Psychophysical Tests Support OCT Findings in Mild Alzheimer's Disease

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García Martín, Elena Salobrar y Hoz Montañana, María Rosa de y Rojas López, María Blanca y Ramírez Sebastián, Ana Isabel y Salazar Corral, Juan José y Yubero Pancorbo, Raquel y Gil Gregorio, Pedro y Triviño Casado, Alberto y Ramirez Sebastian, Jose Manuel (2015) Ophthalmologic Psychophysical Tests Support OCT Findings in Mild Alzheimer's Disease. Journal of Ophthalmology, 2015 . pp. 1-10. ISSN 2090-004X

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URL Oficial: http://dx.doi.org/10.1155/2015/736949




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Purpose. To analyze in mild Alzheimer's disease (MAD) patients, GDS-4 (Reisberg Scale), whether or not some psychophysical tests (PTs) support OCT macular findings in the same group of MAD patients reported previously. Methods. Twenty-three MAD patients and 28 age-matched control subjects with mean Mini Mental State Examination of 23.3 and 28.2, respectively, with no ocular disease or systemic disorders affecting vision were included. Best-corrected visual acuity (VA), contrast sensitivity (CS) (3, 6, 12, and 18 cpds), color perception (CP), and perception digital test (PDT) were tested in one eye of each patient. Results. In comparison with the controls, MAD patients presented (i) a significant decrease in VA, PDT, and CS for all spatial frequencies analyzed, especially the higher ones, and (ii) a significant increase in unspecific errors on the blue axis (P < 0.05 in all instances). In MAD patients, a wide a ROC curve was plotted in all PTs. Conclusions. In MAD, CS, VA, and the tritan axis in CP were impaired. The PTs with the greatest predictive value are the higher spatial frequencies in CS and tritan unspecific errors in CP. PT abnormalities are consistent with the structural findings reported in the same MAD patients using OCT.


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Copyright © 2015 Elena Salobrar-Garcia et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Palabras clave:OCT; Optical Coherence Tomography; Nerve-Fiber Layer; Contrast Sensivity; COognitive Impairment; Visual Dysfunction; Retinal Pathology; Senile Dementia; Alzheimer;
Materias:Ciencias Biomédicas > Medicina > Diagnóstico por imagen y medicina nuclear
Ciencias Biomédicas > Medicina > Geriatría
Ciencias Biomédicas > Medicina > Neurociencias
Ciencias Biomédicas > Medicina > Oftalmología
Ciencias Biomédicas > Óptica y optometría > Anatomía ocular
Ciencias Biomédicas > Óptica y optometría > Técnicas de la imagen
Código ID:31233
Depositado:03 Jul 2015 09:50
Última Modificación:07 Jul 2015 11:28

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