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The Spanish biology/disease initiative within the human proteome project: Application to rheumatic diseases

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Ruiz Romero, Cristina and Calamia, Valentina and Albar, Juan P. and Casal, J. Ignacio and Corrales, F. J. and Fernández Puente, Patricia and Gil, Concha and Mateos, Jesús and Vivanco, Fernando and Blanco, F. (2015) The Spanish biology/disease initiative within the human proteome project: Application to rheumatic diseases. Journal of Proteomics, 127 (Part B). pp. 406-413. ISSN 1874-3919 (In Press)

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Official URL: http://dx.doi.org/10.1016/j.jprot.2015.01.023




Abstract

The Spanish Chromosome 16 consortium is integrated in the global initiative Human Proteome Project, which aims to develop an entire map of the proteins encoded following a gene-centric strategy (C-HPP) in order to make progress in the understanding of human biology in health and disease (B/D-HPP). Chromosome 16 contains many genes encoding proteins involved in the development of a broad range of diseases, which have a significant impact on the health care system. The Spanish HPP consortium has developed a B/D platform with five programs focused on selected medical areas: cancer, obesity, cardiovascular, infectious and rheumatic diseases. Each of these areas has a clinical leader associated to a proteomic investigator with the responsibility to get a comprehensive understanding of the proteins encoded by Chromosome 16 genes. Proteomics strategies have enabled great advances in the area of rheumatic diseases, particularly in osteoarthritis, with studies performed on joint cells, tissues and fluids.

BIOLOGICAL SIGNIFICANCE:

In this manuscript we describe how the Spanish HPP-16 consortium has developed a B/D platform with five programs focused on selected medical areas: cancer, obesity, cardiovascular, infectious and rheumatic diseases. Each of these areas has a clinical leader associated to a proteomic investigator with the responsibility to get a comprehensive understanding of the proteins encoded by Chromosome 16 genes. We show how the Proteomic strategy has enabled great advances in the area of rheumatic diseases, particularly in osteoarthritis, with studies performed on joint cells, tissues and fluids. This article is part of a Special Issue entitled: HUPO 2014.


Item Type:Article
Uncontrolled Keywords:Cartilage, Chondrocyte, Human proteome project, Osteoarthritis, Rheumatic diseases, Synovial fluid
Subjects:Medical sciences > Pharmacy > Microbiology
ID Code:33569
Deposited On:16 Nov 2015 11:10
Last Modified:09 Sep 2019 23:01

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