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Influence of age on IgE response in peanut-allergic children and adolescents from the Mediterranean area

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García-Blanca, A. and Aranda, A. and Blanca-Lopez, N. and Pérez, D. and Gómez, F. and Mayorga, C. and Torres, M.J. and Díaz-Perales, A. and Perkins, J.R. and Villalba, Mayte and Blanca, M. and Canto, G. (2015) Influence of age on IgE response in peanut-allergic children and adolescents from the Mediterranean area. Pediatric Allergy and Immunology, 26 (6). pp. 497-502. ISSN 0905-6157(Print) 1399-3038 (on line)

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Official URL: http://onlinelibrary.wiley.com/doi/10.1111/pai.12418/abstract



Abstract

Background: Peanut allergens are common responsible of food allergy. Analyses of sensitization patterns, relationships with other allergens, clinical symptoms and variation with age are needed. We studied sensitization to Ara h 2, Ara h 9 and Pru p 3 in a population of children/adolescents allergic to peanut, and the relation with peach and pollen.
Methods: Patients allergic to peanut were classified into two groups: A) allergic to peanut, and B) allergic to peach and peanut. The IgE response was measured to Ara h 2, Ara h 9 and Pru p 3.
Results: Of 456 subjects evaluated, 28% were allergic to peanut. From this group 69% were sensitized to pollen. Urticaria was the most frequent entity followed by anaphylaxis and OAS. Fifty-nine percent had Ara h 2 and/or Ara h 9 specific IgE. Over half reported symptoms with peanut alone (Group A); 46% to peanut and peach (Group B). We observed significant differences in sex, age, onset of symptoms and sensitization to Artemisia. IgE response to Ara h 2 was more frequent in Group A; Ara h 9 and Pru p 3 in Group B. We observed a decrease in sensitization to Ara h 2 and an increase to Ara h 9 and Pru p 3 with increasing age.
Conclusion: Peanut allergy is frequent in subjects with allergy to plant-foods, with Ara h 2 and Ara h 9 being two important allergens. In younger patients Ara h 2 predominates over Ara h 9. The reverse was observed in older patients.


Item Type:Article
Uncontrolled Keywords:Food allergy, peanut, peach, allergens, sensitization, LTP, SSP
Subjects:Medical sciences > Medicine > Allergy
Medical sciences > Medicine > Biochemistry
ID Code:33573
Deposited On:16 Oct 2015 11:55
Last Modified:22 Jul 2016 23:01

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