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A unified nomenclature and amino acid numbering for human PTEN.

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Pulido, Rafael y Baker, Suzanne J. y Barata, Joao T. y Carracedo, Arkaitz y Cid, Víctor J. y Chin-Sang, Ian D. y Davé, Vrushank y Hertog, Jeroen den y Devreotes, Peter y Eickholt, Britta J. y Eng, Charis y Furnari, Frank B. y Georgescu, María Magdalena y Gericke, Arne y Hopkins, Benjamin y Jiang, Xeujun y Lee, Seung Rock y Lösche, Mathias y Malaney, Prerna y Matias Guiu, Xavier y Molina, María y Pandolfi, Pier Paolo y Parsons, Ramon y Pinton, Paolo y Rivas, Carmen y Rocha, Rafael M. y Rodríguez, Manuel S. y Ross, Alonzo H. y Serrano, Manuel y Stambolic, Vuk y Stiles, Bangyan y Suzuki, Akira y Tan, Seong Seng y Tonks, Nicholas K. y Trotman, Lloyd C. y Wolff, Nicolas y Woscholski, Rudiger y Wu, Hong y Leslie, Nicholas R. (2014) A unified nomenclature and amino acid numbering for human PTEN. Science signaling, 7 (332). pe15. ISSN 1945-0877

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URL Oficial: http://dx.doi.org/10.1126/scisignal.2005560



Resumen

The tumor suppressor PTEN is a major brake for cell transformation, mainly due to its phosphatidylinositol 3,4,5-trisphosphate [PI(3,4,5)P3] phosphatase activity that directly counteracts the oncogenicity of phosphoinositide 3-kinase (PI3K). PTEN mutations are frequent in tumors and in the germ line of patients with tumor predisposition or with neurological or cognitive disorders, which makes the PTEN gene and protein a major focus of interest in current biomedical research. After almost two decades of intense investigation on the 403-residue-long PTEN protein, a previously uncharacterized form of PTEN has been discovered that contains 173 amino-terminal extra amino acids, as a result of an alternate translation initiation site. To facilitate research in the field and to avoid ambiguities in the naming and identification of PTEN amino acids from publications and databases, we propose here a unifying nomenclature and amino acid numbering for this longer form of PTEN.


Tipo de documento:Artículo
Palabras clave:PTEN, unified nomenclature, amino acid numbering
Materias:Ciencias Biomédicas > Farmacia > Microbiología
Código ID:33631
Depositado:26 Nov 2015 11:54
Última Modificación:26 Nov 2015 11:54

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