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Macro- and microglial responses in the fellow eyes contralateral to glaucomatous eyes

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Ramírez Sebastián, Ana Isabel and Salazar Corral, Juan José and Hoz Montañana, María Rosa de and Rojas López, María Blanca and Gallego Collado, Beatriz Isabel and García Martín, Elena Salobrar and Valiente Soriano, Francisco Javier and Triviño Casado, Alberto and Ramirez Sebastian, Jose Manuel (2015) Macro- and microglial responses in the fellow eyes contralateral to glaucomatous eyes. In Progress in Brain Research. Elsevier, Amsterdam, pp. 155-172. ISBN 978-0-444-63566-2

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Official URL: http://dx.doi.org/10.1016/bs.pbr.2015.05.003




Abstract

Most studies employing experimental models of unilateral glaucoma have used the normotensive contralateral eye as the normal control. However, some studies have recently reported the activation of the retinal macroglia and microglia in the uninjured eye, suggesting that the eye contralateral to experimental glaucoma should not be used as a control. This review analyzes the studies describing the contralateral findings and discusses some of the routes through which the signals can reach the contralateral eye to initiate the glial reactivation.


Item Type:Book Section
Additional Information:

Book series. ISSN: 0079-6123

Uncontrolled Keywords:Experimental glaucoma, Retina, Macroglia, Microglia, Astrocytes, Mu ̈ller cells, Inflamma-tion, Contralateral eye, ACAID, Blood-retinal barrier, Immune system
Subjects:Medical sciences > Medicine > Ophtalmology
Medical sciences > Optics > Eyes anatomy
ID Code:38138
Deposited On:06 Jul 2016 08:01
Last Modified:06 Jul 2016 08:37

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