Publication: Virus de la hepatitis C: variabiliad en las regiones del CORE y NS5A y su impacto en la infección por el genotipo 1b
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2016-07-08
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Universidad Complutense de Madrid
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Abstract
La infección por el virus de la hepatitis C (VHC) tiene un gran impacto a nivel mundial, considerándose una de las principales causas de hepatitis crónica, enfermedad hepática terminal y hepatocarcinoma. Hasta la incorporación de los nuevos agentes antivirales, el genotipo 1b era el que tenía tasas más bajas de respuesta viral sostenida (RVS); y a su vez, el de mayor prevalencia en nuestro medio. Lo que ha llevado a la búsqueda de marcadores predictores de respuesta, con el fin de identificar a aquellos pacientes que pudieran beneficiarse del tratamiento. Estudios previos han mostrado que la variabilidad genómica en la región codificante de la proteína C del Core y en la región comprendida entre los aminoácidos 2209 y 2248 (región determinante de la sensibilidad al IFN: ISDR) de la región que codifica la proteína no-‐estructural 5A (NS5A) están relacionados con la respuesta al tratamiento con biterapia. Es por ello, que el objetivo de nuestro estudio es caracterizar a nivel genómico ambas regiones y analizar su impacto en pacientes con infección crónica por el genotipo 1b. Se analizan, además, otros factores basales implicados en la respuesta: sexo, edad y carga viral basal...
Hepatitis C virus (HCV) infects an estimated 170 million people worldwide and is regarded to be one of the main causes of chronic hepatitis, terminal liver disease and hepatocellular carcinoma. Until the new antiviral agents were introduced, the genotype 1b was the most prevalent in our patients and had the lowest sustained viral response (SVR) rates, which led to the search for predictive markers of response to be able to identify patients who might benefit from this treatment. Previous studies have shown that mutations either in the coding region of the C protein of the Core region or in the region between the amino acids 2209 and 2248 (interferon sensitivity-‐determining region: ISDR) of non-‐structural 5A (NS5A) gene of HCV, are related predictive factors of response to the therapy. The aim of this study was to investigate the mutations in both regions and their impact in patients with chronic HCV 1b infection. It furthermore intends, to analyze other factors involved in the response such us gender, age and baseline viral load...
Hepatitis C virus (HCV) infects an estimated 170 million people worldwide and is regarded to be one of the main causes of chronic hepatitis, terminal liver disease and hepatocellular carcinoma. Until the new antiviral agents were introduced, the genotype 1b was the most prevalent in our patients and had the lowest sustained viral response (SVR) rates, which led to the search for predictive markers of response to be able to identify patients who might benefit from this treatment. Previous studies have shown that mutations either in the coding region of the C protein of the Core region or in the region between the amino acids 2209 and 2248 (interferon sensitivity-‐determining region: ISDR) of non-‐structural 5A (NS5A) gene of HCV, are related predictive factors of response to the therapy. The aim of this study was to investigate the mutations in both regions and their impact in patients with chronic HCV 1b infection. It furthermore intends, to analyze other factors involved in the response such us gender, age and baseline viral load...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Medicina, Departamento de Medicina, leída el 22/09/2015