Publication: Estudio de la actividad antioxidante de las aguas mineromedicinales
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2016-07-11
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Universidad Complutense de Madrid
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Abstract
Los Radicales Libres (RLs) son productos residuales del proceso de creación de energía por parte de nuestro organismo que, debido a su gran capacidad reactiva, ejercen una acción oxidante y destructora. Cuando no es posible producir un equilibrio oxidativo entre la acción oxidante de los RLs y la eficacia de las defensas antioxidantes disponibles, se produce el denominado “estrés oxidativo”, factor que contribuye a acentuar el proceso fisiológico del envejecimiento y a explicar la etiología de diversas enfermedades. Una actuación terapéutica con aguas mineromedicinales (AMm) sobre estos sistemas oxidantes, podría abrir nuevas formas de tratar la enfermedad y de retrasar la aparición del proceso fisiológico del envejecimiento. Estudios realizados por el IMSERSO, han descrito el ahorro por disminución del consumo de fármacos durante los meses siguientes a una cura crenoterápica de 14 días, y otros estudios han hecho extensibles estos resultados a la disminución de absentismo laboral y en visitas post-crenoterapia a Centros de Salud. Más recientemente, se han demostrado los efectos antioxidantes de las AMm sulfuradas y bicarbonatadas-sulfatadas en seres humanos. Es probable que las características físico-químicas de las AMm tengan un papel primordial en la obtención de estos resultados en pacientes y por qué no, que las propias AMm presenten una actividad antioxidante per se. Si así fuera, se abrirían nuevas puertas terapéuticas a un futuro inmediato, al poder anticipar y asegurar si la aplicación terapéutica de una determinada AMm tendrá o no efectos antioxidantes sobre el organismo y en qué proporciones, procediendo a su prescripción...
Free radicals (FRs) are residual products of the process of creating energy by our body that, due to their high reactive capacity, exert an oxidizing and destructive action. When it is not possible to produce an oxidative balance between the oxidizing action of the FRs and the efficacy of the antioxidant defenses available, the so-called "oxidative stress" occurs. It contributes to and accentuates the physiological process of aging and explains the etiology of various diseases. A therapeutic effect of medicinal mineral water (MMW) on these oxidizing systems may open new ways to treat diseases and delay the onset of the physiological process of aging. Studies by the IMSERSO have described savings resulting from a decrease in the consumption of medication in the months following a 14-day spa treatment, and other studies have extended these results to decreased absenteeism and decrease in healthcare center visits. More recently, antioxidant effects of sulfur and bicarbonate-sulfated MMWs have been demonstrated in humans. It is likely that the physicochemical characteristics of MMWs play a key role in obtaining these results in patients and that the MMWs may even exhibit an antioxidant activity per se. If that was the case, we may be able to anticipate whether the therapeutic application of a particular MMW will have antioxidant effects on the body or not and in what proportions, and the MMW prescription may open new therapeutic doors in the immediate future...
Free radicals (FRs) are residual products of the process of creating energy by our body that, due to their high reactive capacity, exert an oxidizing and destructive action. When it is not possible to produce an oxidative balance between the oxidizing action of the FRs and the efficacy of the antioxidant defenses available, the so-called "oxidative stress" occurs. It contributes to and accentuates the physiological process of aging and explains the etiology of various diseases. A therapeutic effect of medicinal mineral water (MMW) on these oxidizing systems may open new ways to treat diseases and delay the onset of the physiological process of aging. Studies by the IMSERSO have described savings resulting from a decrease in the consumption of medication in the months following a 14-day spa treatment, and other studies have extended these results to decreased absenteeism and decrease in healthcare center visits. More recently, antioxidant effects of sulfur and bicarbonate-sulfated MMWs have been demonstrated in humans. It is likely that the physicochemical characteristics of MMWs play a key role in obtaining these results in patients and that the MMWs may even exhibit an antioxidant activity per se. If that was the case, we may be able to anticipate whether the therapeutic application of a particular MMW will have antioxidant effects on the body or not and in what proportions, and the MMW prescription may open new therapeutic doors in the immediate future...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Farmacia, Departamento de Nutrición y Bromatología II (Bromatología), leída el 15/12/2015