Publication: Efecto anestésico en el dispositivo de asistencia mecánica circulatoria: anestesia intravenosa frente a anestesia inhalatoria. Estudio experimental
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2016-07-18
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Universidad Complutense de Madrid
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Abstract
Los dispositivos de asistencia mecánica circulatoria (AMC) son una opción terapéutica prometedora para los pacientes con insuficiencia cardíaca avanzada. Pueden actuar como puente al trasplante, como terapia de destino para los pacientes con contraindicaciones para el trasplante, o como un puente hacia un futuro de recuperación. En las últimas décadas, las AMC se han utilizado cada vez más en los pacientes con insuficiencia cardíaca terminal, ya que el trasplante cardiaco está limitado por una falta de donantes. El principal objetivo de una AMC es mantener la perfusión de los órganos vitales. Para mejorar la salida clínica de la AMC, es necesario optimizar las condiciones perioperatorias (AMC de flujo continuo, monitores hemodinámicos, y los fármacos anestésicos) en la implantación de estos dispositivos. Aunque varios estudios muestran los efectos de la AMC en el flujo de los órganos (corazón, cerebro, hígado y riñón), el efecto de los anestésicos en el flujo de los órganos en pacientes con una AMC no ha sido analizado hasta la fecha...
Ventricular assist devices (VAD) are a promising therapeutic option for patients with advanced heart failure. VAD can act as a bridge to transplantation, as a destination therapy for patients with contraindications to transplantation, or as a bridge to a future recovery. In the last few decades, VADs have been increasingly used in patients with end-stage heart failure, because heart transplantation is limited by a marked lack of donors. The main purpose of a VAD is to maintain perfusion of vital organs. To improve the clinical output of the VAD, it is necessary to optimize perioperative conditions (continuous-flow VAD, hemodynamic monitors, and anesthetic drugs). Although several studies show the effects of the VAD on organ blood flow (heart, brain, liver, and kidney), the effect of anesthetics on organ blood flow in patients with a VAD has not been analyzed to date. Several studies have reported data on the response of organ blood flow to the administration of various anesthetics, although this effect remains unclear for VAD...
Ventricular assist devices (VAD) are a promising therapeutic option for patients with advanced heart failure. VAD can act as a bridge to transplantation, as a destination therapy for patients with contraindications to transplantation, or as a bridge to a future recovery. In the last few decades, VADs have been increasingly used in patients with end-stage heart failure, because heart transplantation is limited by a marked lack of donors. The main purpose of a VAD is to maintain perfusion of vital organs. To improve the clinical output of the VAD, it is necessary to optimize perioperative conditions (continuous-flow VAD, hemodynamic monitors, and anesthetic drugs). Although several studies show the effects of the VAD on organ blood flow (heart, brain, liver, and kidney), the effect of anesthetics on organ blood flow in patients with a VAD has not been analyzed to date. Several studies have reported data on the response of organ blood flow to the administration of various anesthetics, although this effect remains unclear for VAD...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Medicina, Departamento de Farmacología, leída el 27/11/2015