Publication: Desarrollo de nuevas formulaciones tópicas de anfotericina B para el tratamiento de micosis
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2016-08-05
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Universidad Complutense de Madrid
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Abstract
Las infecciones por hongos se han convertido en un tema de gran preocupación en todo el mundo, se estima que más de 40 millones de personas sufren infecciones por hongos, tanto en países desarrollados como en países en vías de desarrollo (Güngör, et al., 2013). Las micosis superficiales se encuentran entre las formas más frecuentes de infecciones en los humanos. Se estima que afectan un 20-25 % de la población mundial y su incidencia está constantemente en aumento (Vena, et al., 2012) (Havlickova, et al., 2008) (Das, et al., 2007). Actualmente, este tipo de infecciones son un frecuente motivo de consulta para el médico de familia (Hernández, et al., 2014) y el dermatólogo. Lo cual nos obliga a permanecer constantemente actualizados La candidiasis es la micosis emergente con mayor efecto en el ser humano debido a su frecuencia y a la gravedad de sus complicaciones (López-Martínez, R., 2010). La candidiasis superficial es una de las formas clínicas más comunes. Es característicamente crónica y recurrente, y, a veces, indica el comienzo de las formas graves de esta micosis (Pappas, et al., 2009). Las levaduras del género Candida son microorganismos pertenecientes a la microbiota normal de individuos sanos, principalmente en la mucosa oral, el tracto gastrointestinal y el tracto genitourinario femenino (Shao, et al., 2007). Sin embargo, estos hongos son responsables de diferentes manifestaciones clínicas, especialmente en pacientes inmunocomprometidos, que van desde infecciones de la piel y mucosas a infecciones sistémicas (Sardi, et al., 2013). Su importancia viene de la alta frecuencia con que colonizan e infectan el huésped humano (De Bernardis, et al., 2004), siendo el cuarto patógeno más común asociado con los casos de infección nosocomial (Wisplinghoff, et al., 2004)...
Fungal infections have become an issue of great concern around the world; it is estimated that over 40 million people do in fact suffer fungal infections both in developed and in developing countries (Güngör, et al., 2013). Superficial fungal infections are among the most common forms of infection in humans. They are believed to affect 20 to 25 % of the world's population, and the incidence continues to increase (Vena, et al., 2012) (Havlickova, et al., 2008) (Das, et al., 2007). Currently, these infections are a frequent cause for consulting a family doctor (Hernández, et al., 2014) and the dermatologist. Therefore, we must stay regularly updated. Candidosis is the emerging mycosis that has the greatest effect in humans due to its frequency and the severity of its complications (López-Martínez, R., 2010). Superficial candidosis is one of the most common clinical forms. It is characteristically chronic and recurrent, and at times, it indicates the beginning of severe forms of this micosis (Pappas, et al., 2009). Candida yeasts are microorganisms belonging to the normal microbiota of healthy individuals, mainly in the oral mucosa, the gastrointestinal tract and the female genitourinary tract (Shao, et al., 2007). However, these fungi are responsible for different clinical manifestations, especially in immunocompromised patients, ranging from skin and mucous infections to systemic infections (Sardi, et al., 2013). Its importance lies in the high frequency with which colonize and infect the human host (De Bernardis, et al., 2004), becoming the fourth most commonly associated pathogen with nosocomial infection (Wisplinghoff, et al., 2004)...
Fungal infections have become an issue of great concern around the world; it is estimated that over 40 million people do in fact suffer fungal infections both in developed and in developing countries (Güngör, et al., 2013). Superficial fungal infections are among the most common forms of infection in humans. They are believed to affect 20 to 25 % of the world's population, and the incidence continues to increase (Vena, et al., 2012) (Havlickova, et al., 2008) (Das, et al., 2007). Currently, these infections are a frequent cause for consulting a family doctor (Hernández, et al., 2014) and the dermatologist. Therefore, we must stay regularly updated. Candidosis is the emerging mycosis that has the greatest effect in humans due to its frequency and the severity of its complications (López-Martínez, R., 2010). Superficial candidosis is one of the most common clinical forms. It is characteristically chronic and recurrent, and at times, it indicates the beginning of severe forms of this micosis (Pappas, et al., 2009). Candida yeasts are microorganisms belonging to the normal microbiota of healthy individuals, mainly in the oral mucosa, the gastrointestinal tract and the female genitourinary tract (Shao, et al., 2007). However, these fungi are responsible for different clinical manifestations, especially in immunocompromised patients, ranging from skin and mucous infections to systemic infections (Sardi, et al., 2013). Its importance lies in the high frequency with which colonize and infect the human host (De Bernardis, et al., 2004), becoming the fourth most commonly associated pathogen with nosocomial infection (Wisplinghoff, et al., 2004)...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Farmacia, Departamento de Farmacia y Tecnología Farmacéutica, leída el 26-01-2016