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Estudio de la infección "Clostridium difficile": incidencia, epidemiología, características clínicas, factores de riesgo de gravedad y recurrencia

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Reigadas Ramírez, Elena (2016) Estudio de la infección "Clostridium difficile": incidencia, epidemiología, características clínicas, factores de riesgo de gravedad y recurrencia. [Thesis]

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Abstract

Clostridium difficile causes a broad range of diseases in humans, from mild colitis to pseudomembranous colitis and disease refractory to treatment, fulminant and fatal. It is an infection whose frequency, seriousness and related morbidity and mortality have increased in recent years [1-4]. Nowadays it is regarded as an emerging public health problem, and prevention and monitoring are particularly recommended. In recent years, different authors have described a change in its epidemiology, which affects not only the populations traditionally involved, but also children and patients from the community [2, 5]. Moreover, the Spanish situation has proven to be different, in terms of the ribotypes present, to other countries in Europe, Canada and the USA. Thus, the performance of an in-depth study in this type of patients in Spain, as well as the source of the acquisition of Clostridium difficile infection (CDI), is of major relevance. The main predisposing factor to acquiring CDI is the use of antibiotics in the previous 8 weeks (90% cases in some series), even with a single prophylactic dose. Other risk factors are a previous stay in health-care centers, particularly hospitals, being old and immunodepression, including transplantations and HIV [6]. The severity of CDI has been associated both with host factors and microorganism-specific factors...


Item Type:Thesis
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Medicina, leída el 01/12/2015

Directors:
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Bouza Santiago, Emilio
Uncontrolled Keywords:Clostridiosis, Clostridium difficile, colitis
Palabras clave (otros idiomas):Clostridium Disease, colitis
Subjects:Medical sciences > Medicine > Communicable diseases
ID Code:38927
Deposited On:26 Aug 2016 12:25
Last Modified:26 Aug 2016 12:25

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