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Diadenosine Polyphosphates in Tears of Sjögren Syndrome Patients

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Carracedo Rodríguez, Juan Gonzalo and Peral Cerdá, Assumpta and Pintor, Jesús (2010) Diadenosine Polyphosphates in Tears of Sjögren Syndrome Patients. Investigative Ophthalmology & Visual Science, 51 (11). pp. 5452-5459. ISSN 0146-0404

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Official URL: http://dx.doi.org/10.1167/iovs.09-5088




Abstract

Purpose.: To analyze the levels of diadenosine tetraphosphate (Ap4A) and diadenosine pentaphosphate (Ap5A) in tears of subjects with Sjögren syndrome and to compare them with those in a control group.
Methods.: Twelve subjects with a diagnosis of Sjögren syndrome and 20 healthy control subjects were invited to participate in the present study. Schirmer strips were used to measure tear secretion (Schirmer I test) and to collect tears. Ap4A and Ap5A were measured by high-pressure liquid chromatography (HPLC), and a dry eye questionnaire (DEQ) was used to evaluate dry eye symptomatology.
Results.: The mean concentrations of Ap4A and Ap5A in the Sjögren syndrome group were 2.54 ± 1.02 and 26.13 ± 6.95 μM, respectively. This group of patients was divided in two subgroups: four patients with normal tear production and eight patients with low tear production. Concentrations of Ap4A, and Ap5A in patients with normal tear production (Schirmer test result, 12.3 ± 1.2 mm) were 0.47 ± 0.20 and 8.03 ± 3.27 μM, respectively. In the patients with low tear production (Schirmer test result, 1.0 ± 0.3 mm), the concentrations were 4.09 ± 1.36 and 39.51 ± 8.46 μM, respectively and in the control group, 0.13 ± 0.03 and 0.04 ± 0.02 μM, respectively.
Conclusions.: Patients with Sjögren syndrome have abnormally elevated concentrations of diadenosine polyphosphates, indicating that these compounds could be used in the diagnosis of this disease.


Item Type:Article
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Uncontrolled Keywords:Diadenosine poliphsophates ; Tears ; Sjödren syondrome ; Eye
Subjects:Sciences > Chemistry > Chemistry, Organic
Medical sciences > Medicine > Biochemistry
Medical sciences > Medicine > Ophtalmology
ID Code:39546
Deposited On:21 Oct 2016 09:30
Last Modified:21 Oct 2016 09:30

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